Tight junctions have long been regarded as simple barriers that separate compartments of
different compositions, but recent research indicates that different types of signalling proteins …

The tight junction is an intracellular junctional structure that mediates adhesion between
epithelial cells and is required for epithelial cell function. Tight junctions control paracellular …

The generation of membrane domains with distinct protein constituents is a hallmark of cell
polarization. In epithelia, segregation of membrane proteins into apical and basolateral …

▪ Abstract Adherens junctions are specialized forms of cadherin-based adhesive contacts
important for tissue organization in developing and adult organisms. Cadherins form protein …

Adhesive interactions between cells are dynamic and regulated during tissue development
and homeostasis. Cadherins are major cell–cell adhesion molecules involved in the …

Proteolytic processing of amyloid precursor protein (APP) generates amyloid-β peptide and
has been implicated in the pathogenesis of Alzheimer's disease. However, the normal …

▪ Abstract The polarized architecture of epithelial cells and tissues is a fundamental
determinant of animal anatomy and physiology. Recent progress made in the genetic and …

The establishment and maintenance of polarity is of fundamental importance for the function
of epithelial and neuronal cells. In Drosophila, the multi-PDZ domain protein Bazooka (Baz) …

Polarized cells contain numerous membrane domains, but it is unclear how the formation of
these domains is coordinated to create a single integrated cell architecture. Genetic screens …

The apical transmembrane protein Crumbs is a central regulator of epithelial apical–basal
polarity in Drosophila. Loss-of-function mutations in the human homologue of Crumbs …