Epigallocatechin-3-gallate prevents cardiac apoptosis by modulating the intrinsic apoptotic pathway in isoproterenol-induced myocardial infarction

AI Othman, MM Elkomy, MA El-Missiry… - European Journal of …, 2017 - Elsevier
Epigallocatechin-gallate (EGCG) is an emerging natural therapy. This study examined the
cardioprotective effect of EGCG on isoproterenol-induced myocardial damage and …

Combined carvacrol and cilostazol ameliorate ethanol-induced liver fibrosis in rats: Possible role of SIRT1/Nrf2/HO-1 pathway

SE Abu-Risha, SS Sokar, HR Elbohoty… - International …, 2023 - Elsevier
Carvacrol is a natural phenolic monoterpenoid, and cilostazol is a selective
phosphodiesterase-3 inhibitor with antioxidant, anti-inflammatory and antiapoptotic effects …

Starch based hydrogel NPs loaded by anthocyanins might treat glycogen storage at cardiomyopathy in animal fibrotic model

NAN Hanafy - International Journal of Biological Macromolecules, 2021 - Elsevier
Many reports have been published recently confirmed the limitation of cargo molecules
delivered into the heart. This failure is mostly associated with lymphatic or vascular channels …

Starch-based hydrogel nanoparticles loaded with polyphenolic compounds of Moringa oleifera leaf extract have hepatoprotective activity in bisphenol A-induced …

HMH Abou El-Naga, SA El-Hashash, EM Yasen… - Polymers, 2022 - mdpi.com
Bisphenol A (BPA) is an xenoestrogenic chemical used extensively in the fabrication of baby
bottles, reusable plastic water bottles and polycarbonate plastic containers. The current …

Pomegranate action in curbing the incidence of liver injury triggered by Diethylnitrosamine by declining oxidative stress via Nrf2 and NFκB regulation

H Husain, U Latief, R Ahmad - Scientific reports, 2018 - nature.com
Unearthing and employment of healthy substitutes is now in demand to tackle a number of
diseases due to the excessive repercussions of synthetic drugs. In this frame of reference …

Betaine treatment decreased oxidative stress, inflammation, and stellate cell activation in rats with alcoholic liver fibrosis

İ Bingül, C Başaran-Küçükgergin, AF Aydın… - Environmental …, 2016 - Elsevier
The aim of this study was to investigate the effect of betaine (BET) on alcoholic liver fibrosis
in rats. Fibrosis was experimentally generated with ethanol plus carbon tetrachloride (ETH+ …

MiR-155 aggravated septic liver injury by oxidative stress-mediated ER stress and mitochondrial dysfunction via targeting Nrf-2

ZB Yang, WW Chen, HP Chen, SX Cai, JD Lin… - … and Molecular Pathology, 2018 - Elsevier
Objective Liver is uniquely vulnerable during sepsis. MicroRNA-155 (miR-155) is confirmed
to play crucial roles in septic liver injury. The present study aims to investigate the …

[HTML][HTML] Amplifying hepatic L-aspartate levels suppresses CCl4-induced liver fibrosis by reversing glucocorticoid receptor β-mediated mitochondrial malfunction

R Su, HL Fu, QX Zhang, CY Wu, GY Yang, JJ Wu… - Pharmacological …, 2024 - Elsevier
Liver fibrosis is a determinant-stage process of many chronic liver diseases and affected
over 7.9 billion populations worldwide with increasing demands of ideal therapeutic agents …

Epigallocatechin-3-gallate upregulates miR-221 to inhibit osteopontin-dependent hepatic fibrosis

ML Arffa, MA Zapf, AN Kothari, V Chang, GN Gupta… - PloS one, 2016 - journals.plos.org
Osteopontin (OPN) promotes hepatic fibrosis, and developing therapies targeting OPN
expression in settings of hepatic injury holds promise. The polyphenol epigallocatechin-3 …

The effect of Alnus incana (L.) Moench extracts in ameliorating iron overload-induced hepatotoxicity in male albino rats

F Abo-Elghiet, SA Mohamed, NAE Yasin, A Temraz… - Scientific Reports, 2023 - nature.com
Iron overload causes multiorgan dysfunction and serious damage. Alnus incana from the
family Betulaceae, widely distributed in North America, is used for treating diseases. In this …