Oligonucleotide-based therapies are advanced novel interventions used in the management
of various respiratory diseases such as asthma and Chronic Obstructive Pulmonary Disease …

US9572874B2 - Composition comprising a complexed (M)RNA and a naked mRNA for
providing or enhancing an immunostimulatory response in a mammal and uses thereof - Google …

US8968746B2 - Complexation of nucleic acids with disulfide-crosslinked cationic
components for transfection and immunostimulation - Google Patents US8968746B2 …

The present invention relates to an immunostimulating agent comprising at least one
chemically modified RNA. The invention furthermore relates to a vaccine which comprises at …

The present invention relates to nucleic acids of the general formula (I):(N u G l X m G n N v)
a and derivatives thereof as an immunostimulating agent/adjuvant and to compositions …

The present invention relates to a nucleic acid of the general formula (I): GXG., or (II): CXC,
which may be modified by a lipid. The nucleic acid of the invention acts as an immune …

The present invention relates to pharmaceutical compositions comprising at least one
fragment of a polynucleotide, preferably at least one antigen, and optionally a …

The invention relates to immunostimulatory oligonucleotide compositions. These
oligonucleotides comprise an immu nostimulatory octanucleotide Sequence. These …

The invention relates to the therapeutic use of oligonucleotides as immunostimulatory
agents in immunotherapy applications. More particularly, the invention provides …

The invention provides methods and compositions useful for modulating signaling through
Toll-like receptors. The meth ods involve contacting a TLR-expressing cell with a small …