Somatic cell nuclear transfer (SCNT) cloning is the sole reproductive engineering
technology that endows the somatic cell genome with totipotency. Since the first report on …

Somatic cell nuclear transfer (SCNT) has been an area of interest in the field of stem cell
research and regenerative medicine for the past 20 years. The main biological goal of SCNT …

Mammalian oocytes can reprogram somatic cells into a totipotent state enabling animal
cloning through somatic cell nuclear transfer (SCNT). However, the majority of SCNT …

The transfer of somatic cell nuclei into oocytes can give rise to pluripotent stem cells that are
consistently equivalent to embryonic stem cells,,, holding promise for autologous cell …

Somatic cell nuclear transfer (SCNT) enables cloning of differentiated cells by
reprogramming their nuclei to a totipotent state. However, successful full-term development …

Faulty epigenetic reprogramming of somatic nuclei is likely to be a major cause of low
success observed in all mammals produced through somatic cell nuclear transfer (SCNT). It …

Histone deacetylase inhibitors (HDACi) are small molecules that have important and
pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can …

The oocyte cytoplasm can reprogram the somatic cell nucleus into a totipotent state, but with
low efficiency. The spatiotemporal chromatin organization of somatic cell nuclear transfer …

Fertile offspring from somatic cell nuclear transfer (SCNT) is the goal of most cloning
laboratories. For this process to be successful, a number of events must occur correctly. First …

Accumulating evidence suggests that histone hypoacetylation which is partly mediated by
histone deacetylase (HDAC), plays a causative role in the etiology of various clinical …