Therapeutic potential of certain terpenoids as anticancer agents: a scoping review

S Kamran, A Sinniah, MAM Abdulghani, MA Alshawsh - Cancers, 2022 - mdpi.com
Simple Summary Terpenoids are bioactive compounds with a variety of pharmacological
activities, including anticancer activity. This review paper aimed to focus on the anticancer …

Saffron (Crocus sativus L.): A Source of Nutrients for Health and for the Treatment of Neuropsychiatric and Age-Related Diseases

A El Midaoui, I Ghzaiel, D Vervandier-Fasseur, M Ksila… - Nutrients, 2022 - mdpi.com
Saffron (Crocus sativus L.) is a medicinal plant, originally cultivated in the East and Middle
East, and later in some Mediterranean countries. Saffron is obtained from the stigmas of the …

Dietary natural products for prevention and treatment of breast cancer

Y Li, S Li, X Meng, RY Gan, JJ Zhang, HB Li - Nutrients, 2017 - mdpi.com
Breast cancer is the most common cancer among females worldwide. Several
epidemiological studies suggested the inverse correlation between the intake of vegetables …

A comprehensive review on biological activities and toxicology of crocetin

M Hashemi, H Hosseinzadeh - Food and Chemical Toxicology, 2019 - Elsevier
Natural products with high pharmacological potential and low toxicity have been considered
as the novel therapeutic agents. Crocetin is an active constituent of saffron (Crocus sativus …

[HTML][HTML] Isolation, purification and characterization of naturally derived Crocetin beta-d-glucosyl ester from Crocus sativus L. against breast cancer and its binding …

MA Mir, SA Ganai, S Mansoor, S Jan, P Mani… - Saudi Journal of …, 2020 - Elsevier
Saffron plant (Crocus sativus L.) is being used as a source of saffron spice and medicine to
cure or prevent different types of diseases including cancers. We report the isolation …

Advances on the anti-tumor mechanisms of the carotenoid Crocin

X Bao, J Hu, Y Zhao, R Jia, H Zhang, L Xia - PeerJ, 2023 - peerj.com
Saffron is located in the upper part of the crocus stigma of iridaceae, which has a long
history of medicinal use. Crocin (molecular formula C 44 H 64 O 24) is a natural floral …

The natural carotenoid crocetin and the synthetic tellurium compound AS101 protect the ovary against cyclophosphamide by modulating SIRT1 and mitochondrial …

G Di Emidio, G Rossi, I Bonomo… - Oxidative medicine …, 2017 - Wiley Online Library
Cancer therapies are associated with increased infertility risk due to accelerated
reproductive aging. Oxidative stress (OS) is a potential mechanism behind ovarian toxicity …

Comparative assessment of immunomodulatory, proliferative, and antioxidant activities of crocin and crocetin on mesenchymal stem cells

F Yousefi, FL Arab, M Rastin, NS Tabasi… - Journal of Cellular …, 2021 - Wiley Online Library
Saffron (Crocus sativus L) is a well‐known spice with active pharmacologic components
including crocin, crocetin, safranal, and picrocrocin. Similar to crocin/crocetin, mesenchymal …

Evaluation of anti-tumor effects of crocin on a novel 3D tissue-engineered tumor model based on sodium alginate/gelatin microbead

J Zhu, S Zheng, H Liu, Y Wang, Z Jiao, Y Nie… - International Journal of …, 2021 - Elsevier
Crocin, as one of the biologically active components of saffron, has anti-inflammatory, anti-
oxidant, anti-depressant and auxiliary anti-tumor effects. Studies have shown that crocin …

Mitochondrial apoptosis and curtailment of hypoxia‐inducible factor‐1α/fatty acid synthase: A dual edge perspective of gamma linolenic acid in ER+ mammary gland …

S Roy, M Singh, A Rawat, D Kumar… - Cell Biochemistry and …, 2020 - Wiley Online Library
Gamma linolenic acid is a polyunsaturated fatty acid having selective anti‐tumour properties
with negligible systemic toxicity. In the present study, the anti‐cancer potential of gamma …