The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Background Substantial evidence suggests that cognitive deficits might persist after
remission of a major depressive episode. However, results are inconsistent relative to the …

Although there have been tremendous advances in the understanding of human
dysfunctions in the brain circuitry for self-reflection, emotion, and cognitive control, a brain …

Progress in clinical and affective neuroscience is redefining psychiatric illness as
symptomatic expression of cellular/molecular dysfunctions in specific brain circuits. Post …

Background Depression is associated with cognitive deficits across multiple domains,
including working memory. The n-back task, a convenient psychometric tool capable of …

Complex emotional, cognitive and self‐reflective functions rely on the activation and
connectivity of large‐scale neural circuits. These circuits offer a relevant scale of focus for …

Active adaptation to acute stress is essential for coping with daily life challenges. The stress
hormone cortisol, as well as large scale re-allocations of brain resources have been …

Research into the pathophysiology of major depressive disorder (MDD) has focused largely
on individuals already affected by MDD. Studies have thus been limited in their ability to …

Depressive disorders contribute heavily to global disease burden; This is possibly because
patients are often treated homogeneously, despite having heterogeneous symptoms with …

Migraine comorbid with depression is common and is often encountered in clinical practice.
The comorbidity may lead to more serious conditions with other symptoms and a longer …