Theranostic applications of biomolecule‐responsive aggregation‐induced emission luminogens

Y Liao, Z Peng, X Liu, Y Hu… - Interdisciplinary Medicine, 2023 - Wiley Online Library
Highly sensitive and high‐accuracy detection of biomolecular changes is vital for the early
diagnosis and treatment of diverse diseases. Due to their unique advantages and the broad …

Recent Progress of Small‐Molecule Ratiometric Fluorescent Probes for Peroxynitrite in Biological Systems

Q Ma, S Xu, Z Zhai, K Wang, X Liu… - … A European Journal, 2022 - Wiley Online Library
Peroxynitrite (ONOO−) as a major reactive oxygen species plays important roles in cellular
signal transduction and homeostatic regulation. Precise detection of ONOO− in biological …

ONOO--triggered fluorescence H2S donor for mitigating drug-induced liver injury

J Liu, M Zhao, F Zhao, X Song, Y Ye - Sensors and Actuators B: Chemical, 2023 - Elsevier
Scavenging of toxic active substances (ROS and RNS) and releasing of protective H 2 S
may be a potential strategy to mitigate liver injury caused by clinical drugs. Hence, we …

Ex Tenebris Lux: Illuminating Reactive Oxygen and Nitrogen Species with Small Molecule Probes

MC Cabello, G Chen, MJ Melville, R Osman… - Chemical …, 2024 - ACS Publications
Reactive oxygen and nitrogen species are small reactive molecules derived from elements
in the air─ oxygen and nitrogen. They are produced in biological systems to mediate …

Engineering an activatable fluorescent probe for studying ONOO− in pyroptotic process

J Gong, X Wang, HE Fan, J Wang, F Zhang, Z Mao - Talanta, 2024 - Elsevier
Pyroptosis, a recently discovered form of programmed cell death, plays a pivotal role in
oncological treatment. Howbeit, the mechanisms underlying pyroptosis in tumor treatment …

Visualizing intracellular dynamics with AIE probes

MMS Lee, YY Eric, JHC Chau, JWY Lam… - Materials Chemistry …, 2023 - pubs.rsc.org
As a sensitive, selective, and non-invasive method, fluorescence bioimaging stands out in
biological and pathological studies to visualize biological processes on the microscale …

A therapeutic probe for detecting and inhibiting ONOO− in senescent cells

P Huang, Z Li, L Nong, J Cheng, W Lin - Journal of Materials Chemistry …, 2023 - pubs.rsc.org
Aging is an inevitable biological process, characterized by a general decline in the quality of
all physiological functions and reactions involving all organs and tissues of the body …

Advances in fluorescent probe development for bioimaging of potential Parkinson's biomarkers

X Sun, Q Jiang, Y Zhang, J Su, W Liu, J Lv… - European Journal of …, 2024 - Elsevier
Parkinson's disease (PD) is a common neurodegenerative disease. The clinical symptoms
of PD are usually related to motor symptoms, including postural instability, rigidity …

Development of peroxynitrite-responsive fluorescence probe for recognition of drug-induced liver injury

BD Wang, R Wei, MJ Gao, YH Wang, CF Zhang… - … Acta Part A: Molecular …, 2022 - Elsevier
Peroxynitrite (ONOO−) as an active substance, is produced during normal physiological
process, which plays an important role in maintaining cell REDOX balance and cell function …

A highly selective probe for ratiometric imaging peroxynitrite in living cells and in vivo

JQ Xu, MJ Gao, JS Guo, YH Wang, R Wei, YL Meng… - Bioorganic …, 2022 - Elsevier
In this study, we constructed and displayed a ratiometric fluorescent probe JQ-2 for detecting
ONOO−. The probe JQ-2 showed a ratiometric signal for visualizing ONOO− with a rapid …