Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

Cellular senescence occurs in proliferating cells as a consequence of various triggers
including telomere shortening, DNA damage, and inappropriate expression of oncogenes …

For most species, aging promotes a host of degenerative pathologies that are characterized
by debilitating losses of tissue or cellular function. However, especially among vertebrates …

The generation of reactive oxygen species (ROS) and an altered redox status are common
biochemical aspects in cancer cells. ROS can react with the polyunsaturated fatty acids of …

Telomeres in most human cells shorten with each round of DNA replication, because they
lack the enzyme telomerase. This is not, however, the only determinant of the rate of loss of …

Correspondence to S. Bacchetti. research in this field may render the information rapidly
outdated, we hope that the present survey of over 3500 tumour and control samples will aid …

Stem cells are not only units of biological organization, a clonal level are restricted to give
rise to T lymphocytes, responsible for the development and the regeneration B lymphocytes …

Much telomere loss takes place during the period of most rapid growth when cell
proliferation and potentially energy expenditure are high. Fast growth is linked to reduced …

Expression of the p16INK4a tumor suppressor sharply increases with age in most
mammalian tissues, and contributes to an age‐induced functional decline of certain self …

Leukemia can be viewed as a newly formed, abnormal hematopoietic tissue initiated by a
few leukemic stem cells (LSCs) that undergo an aberrant and poorly regulated process of …