Addressing disorders related to the central nervous system (CNS) remains a complex
challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry …

New nanotechnology strategies for enhancing drug delivery in brain disorders have recently
received increasing attention from drug designers. The treatment of neurological conditions …

The nasal route has been investigated as a promising alternative for drug delivery to the
central nervous system, avoiding passage through the blood–brain barrier and improving …

The work aims to develop mucoadhesive and thermo-responsive in situ gelling systems,
using hydrophobically-modified hydroxypropyl-methyl cellulose (Sangelose, SG) and beta …

The nasal route offers many advantages for drug delivery: quick onset of action, better
patient compliance, avoidance of first‐pass metabolism and bypassing the blood‐brain …

The nasal route is commonly used for local drug delivery. However, researchers are
currently exploring this route for systemic and central nervous system (CNS) drug delivery …

A combination of Poloxamer 407 (P407) and hydroxypropyl methylcellulose (HPMC)
hydrosols is proposed as an in situ thermo-gelling vehicle for the nasal drug delivery of …

Winlevi®(clascoterone) topical cream (1%, w/w) was approved by the US FDA for the
treatment of acne vulgaris in patients 12 years of age and older. The active ingredient …

Background Rivastigmine (RT), exhibits low oral availability (40%) and high hepatic first-
pass (36%). Circumventing the blood-brain barrier-related convolutions for successful brain …

Neurological disorders affecting the central nervous system (CNS), such as glioblastoma,
Alzheimer's, Parkinson's, and Huntington's diseases, represent a significant burden on …