The highly contagious disease tuberculosis (TB) is caused by the bacterium Mycobacterium
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …

Significance: The physiological mechanism (s) for recognition and removal of red blood cells
(RBCs) from circulation after 120 days of its lifespan is not fully understood. Many of the …

For cancer cells to survive and proliferate, they must escape normal immune destruction.
One mechanism by which this is accomplished is through immune suppression effected by …

The structural elements which afford molecular recognition and discrimination events in
macromol-ecule-ligand interactions dictate the basis of protein function. Nature has evolved …

Nitric oxide (NO) has been implicated as mediator in a variety of physiological functions,
including neurotransmission, platelet aggregation, macrophage function, and vasodilation …

Neuronal PAS domain protein 2 (NPAS2) is a mammalian transcription factor that binds
DNA as an obligate dimeric partner of BMAL1 and is implicated in the regulation of circadian …

Rate constants for CO-heme binding to 35 different recombinant apomyoglobins and several
other apoproteins were measured in an effort to understand the factors governing heme …

Myoglobin stores O2 in muscles to permit short bursts of metabolism at rates much greater
than those which would be allowed by circulatory oxygen transport. In its native deoxy form …

Iron is an absolute requirement for nearly all organisms, but most bacterial pathogens are
faced with extreme iron-restriction within their host environments. To overcome iron …

Blood transfusion is the key to life in case of traumatic emergencies, surgeries and in several
pathological conditions. An important goal of whole blood or red blood cell transfusion is the …