Transcriptomic response dynamics of human primary and immortalized adrenocortical cells to steroidogenic stimuli
Adrenal steroid hormone production is a dynamic process stimulated by adrenocorticotropic
hormone (ACTH) and angiotensin II (AngII). These ligands initialize a rapid and robust gene …
hormone (ACTH) and angiotensin II (AngII). These ligands initialize a rapid and robust gene …
Small-molecule Ro-08-2750 interacts with many RNA-binding proteins and elicits MUSASHI2-independent phenotypes
RNA-binding proteins (RBPs) are key regulators of gene expression. Small molecules
targeting these RBP–RNA interactions are a rapidly emerging class of therapeutics for …
targeting these RBP–RNA interactions are a rapidly emerging class of therapeutics for …
In situ spatial reconstruction of distinct normal and pathological cell populations within the human adrenal gland
R Fu, K Walters, ML Kaufman, K Koc… - Journal of the …, 2023 - academic.oup.com
The human adrenal gland consists of concentrically organized, functionally distinct regions
responsible for hormone production. Dysregulation of adrenocortical cell differentiation …
responsible for hormone production. Dysregulation of adrenocortical cell differentiation …
Adrenal gene expression dynamics support hibernation in 13-lined ground squirrels
AE Gillen, LE Epperson, DJ Orlicky… - Physiological …, 2023 - journals.physiology.org
Hibernation is a natural model of extreme physiology in a mammal. Throughout winter, small
hibernators repeatedly undergo rapid, dramatic swings in body temperature, perfusion, and …
hibernators repeatedly undergo rapid, dramatic swings in body temperature, perfusion, and …
Small molecule inhibition of multiple RNA binding proteins underlies Musashi-2 independent phenotypes
K Walters, MP Sajek, A Issaian, A Baldwin, E Harrison… - bioRxiv, 2022 - biorxiv.org
ABSTRACT RNA binding proteins (RBPs) are key regulators of gene expression. Small
molecules targeting these RBP-RNA interactions are a rapidly emerging class of …
molecules targeting these RBP-RNA interactions are a rapidly emerging class of …
OR08-02 In Situ Reconstruction Of Distinct Normal And Pathological Cell Populations Within The Human Adrenal Gland Using Spatial Transcriptomics
F Rui, K Walters, K Koc, A Baldwin… - Journal of the …, 2023 - academic.oup.com
Abstract Disclosure: F. Rui: None. K. Walters: None. K. Koc: None. A. Baldwin: Stock Owner;
Self; Tempus Labs. K. Kiseljak-Vassiliades: Advisory Board Member; Self; HRA Pharma. LM …
Self; Tempus Labs. K. Kiseljak-Vassiliades: Advisory Board Member; Self; HRA Pharma. LM …
In vivo and ex vivo molecular analyses of aldosterone producing cells of the adrenal gland, in patients with primary aldosteronism
E Goodchild - 2023 - qmro.qmul.ac.uk
Aldosterone producing micronodules (APM) are the predicted precursor to aldosterone
producing adenomas (APA) and can cause primary aldosteronism (PA) in their own right. PA …
producing adenomas (APA) and can cause primary aldosteronism (PA) in their own right. PA …
The RNA-Binding Protein ZFP36L2 Regulates Human Adrenocortical Steroidogenesis Through Post-Transcriptional Control
KY Wellman - 2022 - search.proquest.com
Aldosterone synthesis must be rapid, robust, and restorable. The molecular mechanisms
that allow for all three qualities are imperative to human health. We investigated the …
that allow for all three qualities are imperative to human health. We investigated the …