Diseases caused by tropical parasites affect hundreds of millions of people worldwide but
have been largely neglected for drug development because they affect poor people in poor …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

The Suzuki reaction of tetrabromothiophene with arylboronic acids provides a regioselective
approach to various 5‐aryl‐2, 3, 4‐tribromothiophenes, symmetrical 2, 5‐diaryl‐3, 4 …

3, 5-Bis (4-amidinophenyl) isoxazole (3) an analogue of 2, 5-bis (4-amidinophenyl) furan
(furamidine) in which the central furan ring is replaced by isoxazole and 42 novel analogues …

Various heterocyclic systems based on natural and unnatural biologically active products
were synthesized by Brønsted acid-promoted cyclization. We have made an attempt to …

The use of T. brucei as model system for molecular and cell biology is regularly producing
new technologies exploitable for diagnosis and new drugs. Drug discovery and …

Human African trypanosomiasis, caused by the eukaryotic parasite Trypanosoma brucei, is
a serious health problem in much of central Africa. The only validated molecular target for …

A statistical analysis of strong and weak hydrogen bonds in the minor groove of DNA was
carried out for a set of 70 drug-DNA complexes. The terms 'strong'and 'weak'pertain to the …

(Cyclobut-1-ene-1, 2-diyl) bis (1-methylimidazolium) tetrafluoroborate is applied as
preligand in palladium-catalyzed cross-coupling reactions starting from …

Novel bisbenzimidazoles (4–6), characterized by 3, 4-ethylenedioxy-extension of thiophene
core, revealed pronounced affinity and strong thermal stabilization effect toward ds-DNA …