Inflammation is a complex and potentially life-threatening condition that involves the
participation of a variety of chemical mediators, signaling pathways, and cell types. The …

Increased exposure to environmental heavy metals and metalloids and their associated
toxicities has become a major threat to human health. Hence, the association of these …

Development of localized inflammatory environments by M1 macrophages in the cardiac
infarction region exacerbates heart failure after myocardial infarction (MI). Therefore, the …

Clinical observations implicate a role of eosinophils in cardiovascular diseases because
markers of eosinophil activation are elevated in atherosclerosis and thrombosis. However …

Thrombosis is a principle cause of cardiovascular disease, the leading cause of morbidity
and mortality worldwide; however, the conventional anti-thrombotic approach often leads to …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

The central importance of iron in the pathophysiology of disease is derived from the ease
with which iron is reversibly oxidized and reduced. This property, while essential for its …

model of heart failure induced by myocardial infarction, anemia was linked to activation of
the TNF-/Fas signaling pathway. 34 The number of bone marrow progenitor cells and the …

Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

BACKGROUND: The prevalence of primary (hereditary) hemochromatosis and secondary
iron overload (hemosiderosis) is reaching epidemic levels worldwide. Iron-overload leads to …