Toward multi-targeted platinum and ruthenium drugs—a new paradigm in cancer drug treatment regimens?

RG Kenny, CJ Marmion - Chemical reviews, 2019 - ACS Publications
While medicinal inorganic chemistry has been practised for over 5000 years, it was not until
the late 1800s when Alfred Werner published his ground-breaking research on coordination …

Therapeutic strategies to overcome taxane resistance in cancer

T Das, U Anand, SK Pandey, CR Ashby Jr… - Drug Resistance …, 2021 - Elsevier
One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …

The chemistry of heterocycles in the 21st century

VN Charushin, EV Verbitskiy, ON Chupakhin… - Uspekhi Khimii, 2024 - mathnet.ru
The chemistry of heterocyclic compounds has traditionally been and remains a bright area of
chemical science in Russia. This is due to the fact that many heterocycles find the widest …

The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer

K Vermeulen, DR Van Bockstaele… - Cell …, 2003 - Wiley Online Library
The cell cycle is controlled by numerous mechanisms ensuring correct cell division. This
review will focus on these mechanisms, ie regulation of cyclin‐dependent kinases (CDK) by …

The influence of natural products upon drug discovery

DJ Newman, GM Cragg, KM Snader - Natural product reports, 2000 - pubs.rsc.org
3 Role of natural products in treatment of diseases 4 Antiinfective agents (including
antimalarials) 4.1 Antibacterials: b-lactams 4.2 Antibacterials: aminoglycosides 4.3 …

Rhodium (III)-catalyzed arene and alkene C− H bond functionalization leading to indoles and pyrroles

DR Stuart, P Alsabeh, M Kuhn… - Journal of the American …, 2010 - ACS Publications
Recently, the rhodium (III)-complex [Cp* RhCl2] 2 1 has provided exciting opportunities for
the efficient synthesis of aromatic heterocycles based on a rhodium-catalyzed C− H bond …

The specificities of protein kinase inhibitors: an update

J Bain, H McLauchlan, M Elliott, P Cohen - Biochemical Journal, 2003 - portlandpress.com
We have previously examined the specificities of 28 commercially available compounds,
reported to be relatively selective inhibitors of particular serine/threonine-specific protein …

Recent developments in indole ring synthesis—methodology and applications

GW Gribble - Journal of the Chemical Society, Perkin Transactions 1, 2000 - pubs.rsc.org
1 Introduction 2 Sigmatropic rearrangements 2.1 Fischer indole synthesis 2.1. 1
Methodology 2.1. 2 Applications 2.1. 3 Mechanism 2.2 Gassman indole synthesis 2.3 Bartoli …

GSK-3 inhibitors: preclinical and clinical focus on CNS

H Eldar-Finkelman, A Martinez - Frontiers in molecular neuroscience, 2011 - frontiersin.org
Inhibiting glycogen synthase kinase-3 (GSK-3) activity via pharmacological intervention has
become an important strategy for treating neurodegenerative and psychiatric disorders. The …

Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease: A …

S Leclerc, M Garnier, R Hoessel, D Marko… - Journal of Biological …, 2001 - ASBMB
The bis-indole indirubin is an active ingredient of Danggui Longhui Wan, a traditional
Chinese medicine recipe used in the treatment of chronic diseases such as leukemias. The …