Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Lipoxygenases (LOXs) are lipid peroxidizing enzymes, implicated in the pathogenesis of
inflammatory and hyperproliferative diseases, which represent potential targets for …

Human reticulocyte 15-lipoxygenase-1 (h15-LOX-1 or ALOX15) and platelet 12-
lipoxygenase (h12-LOX or ALOX12) catalysis of docosahexaenoic acid (DHA) and the …

Lipoxygenases (LOXs) catalyze the (per) oxidation of fatty acids that serve as important
mediators for cell signaling and inflammation. These reactions are initiated by a CH …

Over the last two decades polypharmacology has emerged as a new paradigm in drug
discovery, even though developing drugs with high potency and selectivity toward a single …

Lithraea caustica (Molina) Hook. and Arn.(Anacardiaceae), common name Litre, is an
evergreen endemic plant used in the Mapuche Chilean folk medicine. The stem juice of L …

In lipoxygenases, the topologically conserved C-terminal domain catalyzes the oxidation of
polyunsaturated fatty acids, generating an assortment of biologically relevant signaling …

In this paper, we attempted to develop a novel class of compounds against lipoxygenase, a
key enzyme in the biosynthesis of leukotrienes implicated in a series of inflammatory …

The natural product molecule 2, 4, 6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated
from the medicinal plant Melicope ptel efolia was shown to exhibit potent lipoxygenase …

Background Puccinia arachidis fungus causes rust disease in the peanut plants (Arachis
hypogaea L.), which leads to high yield loss. Metabolomic profiling of Arachis hypogaea was …