ATM in DNA repair in cancer
MH Jin, DY Oh - Pharmacology & therapeutics, 2019 - Elsevier
Alterations in DNA damage response (DDR) pathways are hallmarks of cancer. Incorrect
repair of DNA lesions often leads to genomic instability. Ataxia telangiectasia mutated …
repair of DNA lesions often leads to genomic instability. Ataxia telangiectasia mutated …
[HTML][HTML] Progress towards a clinically-successful ATR inhibitor for cancer therapy
FM Barnieh, PM Loadman, RA Falconer - Current research in …, 2021 - Elsevier
The DNA damage response (DDR) is now known to play an important role in both cancer
development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia …
development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia …
[HTML][HTML] Selective killing of ATM-or p53-deficient cancer cells through inhibition of ATR
PM Reaper, MR Griffiths, JM Long, JD Charrier… - Nature chemical …, 2011 - nature.com
Here we report a comprehensive biological characterization of a potent and selective small-
molecule inhibitor of the DNA damage response (DDR) kinase ATR. We show a profound …
molecule inhibitor of the DNA damage response (DDR) kinase ATR. We show a profound …
Targeting DNA repair pathway in cancer: Mechanisms and clinical application
M Wang, S Chen, D Ao - MedComm, 2021 - Wiley Online Library
Over the last decades, the growing understanding on DNA damage response (DDR)
pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly …
pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly …
Head and neck cancer: from anatomy to biology
The 20th century saw great advances in anatomy‐based (surgery and radiotherapy) and
chemotherapy approaches for treating head and neck squamous cell carcinoma (HNSCC) …
chemotherapy approaches for treating head and neck squamous cell carcinoma (HNSCC) …
Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents
JD Charrier, SJ Durrant, JMC Golec… - Journal of medicinal …, 2011 - ACS Publications
DNA-damaging agents are among the most frequently used anticancer drugs. However,
they provide only modest benefit in most cancers. This may be attributed to a genome …
they provide only modest benefit in most cancers. This may be attributed to a genome …
Targeting ATR in DNA damage response and cancer therapeutics
E Fokas, R Prevo, EM Hammond, TB Brunner… - Cancer treatment …, 2014 - Elsevier
The ataxia telangiectasia and Rad3-related (ATR) plays an important role in maintaining
genome integrity during DNA replication through the phosphorylation and activation of Chk1 …
genome integrity during DNA replication through the phosphorylation and activation of Chk1 …
Trial watch: targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy
G Manic, F Obrist, A Sistigu, I Vitale - Molecular & cellular oncology, 2015 - Taylor & Francis
The ataxia telangiectasia mutated serine/threonine kinase (ATM)/checkpoint kinase 2
(CHEK2, best known as CHK2) and the ATM and Rad3-related serine/threonine kinase …
(CHEK2, best known as CHK2) and the ATM and Rad3-related serine/threonine kinase …
Non-thermal atmospheric pressure plasma induces apoptosis in oral cavity squamous cell carcinoma: Involvement of DNA-damage-triggering sub-G1 arrest via the …
JW Chang, SU Kang, YS Shin, KI Kim, SJ Seo… - Archives of biochemistry …, 2014 - Elsevier
Recent advances in physics have made possible the use of non-thermal atmospheric
pressure plasma (NTP) in cancer research. Although increasing evidence suggests that NTP …
pressure plasma (NTP) in cancer research. Although increasing evidence suggests that NTP …
Three Epstein–Barr virus latency proteins independently promote genomic instability by inducing DNA damage, inhibiting DNA repair and inactivating cell cycle …
B Gruhne, R Sompallae, MG Masucci - Oncogene, 2009 - nature.com
Epstein–Barr virus (EBV) has been implicated in the pathogenesis of human malignancies,
but its contribution to tumorigenesis is not well understood. EBV carriage is associated with …
but its contribution to tumorigenesis is not well understood. EBV carriage is associated with …