Cytoplasmic dyneins, the principal microtubule minus-end-directed motor proteins of the
cell, are involved in many essential cellular processes. The major form of this enzyme is a …

Dyneins are large multi-component microtubule-based molecular motors involved in many
fundamental cellular processes including vesicular transport, mitosis and ciliary/flagellar …

Cytoplasmic dynein is responsible for many aspects of cellular and subcellular movement.
LIS1, NudE, and NudEL are dynein interactors initially implicated in brain developmental …

A PRODUCT encoded at the claret locus in Drosophila is needed for normal chromosome
segregation in meiosis in females and in early mitotic divisions of the embryo1, 2. The …

Axonemal dyneins form the inner and outer rows of arms associated with the doublet
microtubules of motile cilia. These enzymes convert the chemical energy released from …

The role of cytoplasmic dynein in microtubule-based organelle transport was examined
using a reconstituted assay developed from chick embryo fibroblasts. Factors present in a …

This paper represents a preliminary effort in considering how protein motors could harness
thermal fluctuations to generate force and movement. The initial premise for this model is the …

Dynein was extracted from outer arm-less axonemes of the mutant odal and fractionated by
high-pressure liquid chromatography on a MonoQ column into seven distinct subspecies …

LIS1 was first identified as a gene mutated in human classical lissencephaly sequence. LIS1
is required for dynein activity, but the underlying mechanism is poorly understood. Here, we …

Cilia and flagella of most organisms are equipped with two kinds of motor protein complex,
the inner and outer dynein arms. The two arms were previously thought to be similar to each …