Within the superfamily of pentameric ligand-gated ion channels, cholinergic nicotinic
receptors (nAChRs) were classically identified to mediate synaptic transmission in the …

Nicotinic acetylcholine receptors (nAChRs) are a subfamily of pentameric ligand-gated ion
channels with members identified in most eumetazoan clades. In vertebrates, they are …

Polybrominated biphenyl ethers (PBDEs) are new persistent pollutants that are widely exist
in the environment and have many toxic effects. However, their toxicity mechanisms on …

Chronic neuropathic pain is an increasingly prevalent societal issue that responds poorly to
existing therapeutic strategies. The α9α10 nicotinic acetylcholine receptor (nAChR) has …

All animals need to differentiate between exafferent stimuli, which are caused by the
environment, and reafferent stimuli, which are caused by their own movement. In the case of …

In the lateral line system, water motion is detected by neuromast organs, fundamental units
that are arrayed on a fish's surface. Each neuromast contains hair cells, specialized …

Efferent cholinergic neurons inhibit sensory hair cells of the vertebrate inner ear through the
combined action of calcium-permeable α9α10-containing nicotinic acetylcholine receptors …

Excess noise damages sensory hair cells, resulting in loss of synaptic connections with
auditory nerves and, in some cases, hair-cell death. The cellular mechanisms underlying …

The mechanosensory lateral line is a hair cell-based system that is unique to craniates but
shows multiple losses in different species. It is thought to be evolutionary related to the …

The α9α10 nicotinic cholinergic receptor (nAChR) is a ligand-gated pentameric cation-
permeable ion channel that mediates synaptic transmission between descending efferent …