Congenital PAX6-aniridia, initially characterized by the absence of the iris, has progressively
been shown to be associated with other developmental ocular abnormalities and systemic …

The synthesis of gene expression data and cis-regulatory analysis permits the elucidation of
genomic regulatory networks. These networks provide a direct visualization of the functional …

In this report, we demonstrate that an optic cup structure can form by self-organization in
human ESC culture. The human ESC-derived optic cup is much larger than the mouse ESC …

Balanced organogenesis requires the orchestration of multiple cellular interactions to create
the collective cell behaviours that progressively shape developing tissues. It is currently …

At least 30 types of retinal ganglion cells (RGCs) send distinct messages through the optic
nerve to the brain. Available strategies of promoting axon regeneration act on only some of …

Retinal ganglion cells (RGCs), which transfer information from the eye to the brain, are
heterogeneous in structure and function, but developmental studies have generally treated …

The retina in adult mammals, unlike those in lower vertebrates such as fish and amphibians,
is not known to support neurogenesis. However, when injured, the adult mammalian retina …

Purpose.: We sought to determine if human induced pluripotent stem cells (iPSCs) derived
from blood could produce optic vesicle–like structures (OVs) with the capacity to stratify and …

The sequencing of the Strongylocentrotus purpuratus genome provides a unique
opportunity to investigate the function and evolution of neural genes. The neurobiology of …

The three members of the Pou4f family of transcription factors: Pou4f1, Pou4f2, Pou4f3
(Brn3a, Brn3b and Brn3c, respectively) play, during development, essential roles in the …