Cancer stem cells in hepatocellular carcinoma: an overview and promising therapeutic strategies

N Wang, S Wang, MY Li, B Hu, L Liu… - … in medical oncology, 2018 - journals.sagepub.com
The poor clinical outcome of hepatocellular carcinoma (HCC) patients is ascribed to the
resistance of HCC cells to traditional treatments and tumor recurrence after curative …

Cellular and molecular biology of cancer stem cells of hepatocellular carcinoma

KS Jeng, CF Chang, IS Sheen, CJ Jeng… - International journal of …, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death globally. The
cancer stem cells (CSCs) of HCC are responsible for tumor growth, invasion, metastasis …

Mechanisms and clinical trials of hepatocellular carcinoma immunotherapy

SL Huang, YM Wang, QY Wang, GG Feng… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC), one of the most common and lethal tumors worldwide, is
usually not diagnosed until the disease is advanced, which results in ineffective intervention …

[HTML][HTML] Significance of hepatitis virus infection in the oncogenic initiation of hepatocellular carcinoma

CHC Sukowati, KE El-Khobar, SI Ie… - World journal of …, 2016 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death
worldwide. Chronic infection of hepatitis B virus (HBV) and/or hepatitis C virus (HCV) is a …

Epigenetic Switch between SOX2 and SOX9 Regulates Cancer Cell Plasticity

SC Lin, YT Chou, SS Jiang, JL Chang, CH Chung… - Cancer research, 2016 - AACR
Cell differentiation within stem cell lineages can check proliferative potential, but nodal
pathways that can limit tumor growth are obscure. Here, we report that lung cancer cell …

SOX9 expression is superior to other stem cell markers K19 and EpCAM in predicting prognosis in hepatocellular carcinoma

MB Ruzinova, C Ma, EM Brunt, CW Goss… - The American journal …, 2023 - journals.lww.com
Various stem cell markers (eg, epithelial cell adhesion molecule [EpCAM], cytokeratin 19
[K19]) have been reported as predictors of poor prognosis in hepatocellular carcinoma …

[HTML][HTML] Targeted EpCAM-binding for the development of potent and effective anticancer proteins

Z Liu, C Zhang, B Cui, Y Wang, K Lim, K Li… - Biomedicine & …, 2023 - Elsevier
Protein-based cancer therapies are considered an alternative to conventional anticancer
regimens, providing multifunctional properties while showing low toxicity. However, its …

Heterogeneity of hepatic cancer stem cells

CHC Sukowati - Stem Cells Heterogeneity in Cancer, 2019 - Springer
Hepatocellular carcinoma (HCC) is one of the most common cancers with high mortality rate.
It is a heterogeneous cancer with diverse inter-and intra-heterogeneity, also in terms of …

The clinical, prognostic and therapeutic significance of liver cancer stem cells and their markers

I Zarębska, A Gzil, J Durślewicz, D Jaworski… - Clinics and Research in …, 2021 - Elsevier
Hepatocellular carcinoma (HCC) is the fourth most common cause of death among cancers.
The poor prognosis of HCC might be caused by a population of cancer stem cells (CSC) …

Tazemetostat decreases β-catenin and CD13 protein expression in HEPG-2 and Hepatitis B virus-transfected HEPG-2 with decreased cell viability

MN Amin, YM El-Far, M El-Mowafy, A Elgaml - Clinical Epigenetics, 2023 - Springer
Hepatocellular carcinoma (HCC) is one of the global health concerns. Hepatitis B virus
(HBV) is one of the major causes of HCC. Poor clinical outcome of HCC patients is attributed …