At odds with conventional chemotherapeutics, targeted anticancer agents are designed to
inhibit precise molecular alterations that support oncogenesis or tumor progression. Despite …

Tumor microenvironment (TME) is a host for a complex network of heterogeneous stromal
cells with overlapping or opposing functions depending on the dominant signals within this …

Cell cycle proteins that are often dysregulated in malignant cells, such as cyclin-dependent
kinase 4 (CDK4) and CDK6, have attracted considerable interest as potential targets for …

Glioblastoma (GBM) is the most malignant form of glioma. Glioma stem cells (GSCs)
contribute to the initiation, progression, and recurrence of GBM as a result of their self …

The CDK8–cyclin C complex is an important anti-tumor target, but unlike CDK8, cyclin C
remains undruggable. Modulators regulating cyclin C activity directly are still under …

Natural killer (NK) cells play a pivotal role in controlling cancer. Multiple extracellular
receptors and internal signaling nodes tightly regulate NK activation. Cyclin-dependent …

Natural killer (NK) cells lead immune surveillance against cancer and early elimination of
small tumors. Owing to their ability to engage tumor targets without the need of specific …

Natural killer (NK) cells are potent innate immune system effector lymphocytes armed with
multiple mechanisms for killing cancer cells. Given the dynamic roles of NK cells in tumor …

Triple-negative breast cancer (TNBC) is an aggressive malignant disease that is responsible
for approximately 15% of breast cancers. The standard of care relies on surgery and …

Abstract Cyclin-dependent kinase 8 (CDK8) plays an momentous role in transcription
regulation by forming kinase module or transcription factor phosphorylation. A large number …