Protein kinases are key components in cellular signaling pathways as they carry out the
phosphorylation of proteins, primarily on Ser, Thr, and Tyr residues. The catalytic activity of …

Since their characterization as conserved modules that regulate progression through the
eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are …

Reactive oxygen species (ROS) at the right concentration promote cell proliferation in cell
culture, stem cells, and model organisms. However, the mystery of how ROS signaling is …

Eukayotic protein kinases evolved as a family of highly dynamic molecules with strictly
organized internal architecture. A single hydrophobic F-helix serves as a central scaffold for …

Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

Cyclins and cyclin-dependent protein kinases (CDKs) are important regulatory components
that are required for cell cycle progression. The levels of the cell cycle CDKs are generally …

Posttranslational modification by phosphorylation is a ubiquitous regulatory mechanism in
both eukaryotes and prokaryotes. Intracellular phosphorylation by protein kinases, triggered …

Aurora-A is an oncogenic kinase essential for mitotic spindle assembly. It is activated by
phosphorylation and by the microtubule-associated protein TPX2, which also localizes the …

Aggregation of hyperphosphorylated tau is one of the characteristic neuropathological
lesions of Alzheimer's disease and other neurodegenerative disorders. Pharmacological …

Progression through the eukaryotic cell cycle is driven by the orderly activation of cyclin-
dependent kinases (CDKs). For activity, CDKs require association with a cyclin and …