Mass-spectrometry-based proteomics is continuing to make major contributions to the
discovery of fundamental biological processes and, more recently, has also developed into …

The increasing scale and complexity of quantitative proteomics studies complicate
subsequent analysis of the acquired data. Untargeted label-free quantification, based either …

Antiplatelet treatment is of fundamental importance in combatting functions/dysfunction of
platelets in the pathogenesis of cardiovascular and inflammatory diseases. Dysfunction of …

Novel platelet and megakaryocyte transcriptome analysis allows prediction of the full or
theoretical proteome of a representative human platelet. Here, we integrated the established …

The analysis of protein interaction networks is one of the key challenges in the study of
biology. It connects genotypes to phenotypes, and disruption often leads to diseases …

To better understand the involvement of retinal Müller glial (RMG) cells in retinal diseases,
we phenotyped primary porcine RMGs in dependence of cultivation time using different …

How to process and analyze MS data to quantify and statistically compare protein
abundances in bottom-up proteomics has been an open debate for nearly fifteen years. Two …

Drug transporter expression in tissues (in vivo) usually differs from that in cell lines used to
measure transporter activity (in vitro). Therefore, quantification of transporter expression in …

Mass spectrometry has served as a major tool for the discipline of proteomics to catalogue
proteins in an unprecedented scale. With chemical and metabolic techniques for stable …

Label‐free quantification (LFQ) based on data‐independent acquisition workflows currently
experiences increasing popularity. Several software tools have been recently published or …