Cell-based tissue engineering strategies used in the clinical repair of articular cartilage

BJ Huang, JC Hu, KA Athanasiou - Biomaterials, 2016 - Elsevier
One of the most important issues facing cartilage tissue engineering is the inability to move
technologies into the clinic. Despite the multitude of current research in the field, it is known …

Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis

MB Goldring, KB Marcu - Trends in molecular medicine, 2012 - cell.com
Osteoarthritis (OA) is a multifactorial disease subject to the effects of many genes and
environmental factors. Alterations in the normal pattern of chondrocyte gene control in …

MicroRNA-145 regulates chondrogenic differentiation of mesenchymal stem cells by targeting Sox9

B Yang, H Guo, Y Zhang, L Chen, D Ying, S Dong - PloS one, 2011 - journals.plos.org
Chondrogenic differentiation of mesenchymal stem cells (MSCs) is accurately regulated by
essential transcription factors and signaling cascades. However, the precise mechanisms …

The expression and function of microRNAs in chondrogenesis and osteoarthritis

TE Swingler, G Wheeler, V Carmont… - Arthritis & …, 2012 - Wiley Online Library
Objective To use an in vitro model of chondrogenesis to identify microRNAs (miRNAs) with a
functional role in cartilage homeostasis. Methods The expression of miRNAs was measured …

TGF-β1, GDF-5, and BMP-2 stimulation induces chondrogenesis in expanded human articular chondrocytes and marrow-derived stromal cells

MK Murphy, DJ Huey, JC Hu, KA Athanasiou - Stem cells, 2015 - academic.oup.com
Replacement of degenerated cartilage with cell-based cartilage products may offer a long-
term solution to halt arthritis' degenerative progression. Chondrocytes are frequently used in …

PLA short sub-micron fiber reinforcement of 3D bioprinted alginate constructs for cartilage regeneration

A Kosik-Kozioł, M Costantini, T Bolek, K Szöke… - …, 2017 - iopscience.iop.org
In this study, we present an innovative strategy to reinforce 3D-printed hydrogel constructs
for cartilage tissue engineering by formulating composite bioinks containing alginate and …

microRNA-140 Targets RALA and Regulates Chondrogenic Differentiation of Human Mesenchymal Stem Cells by Translational Enhancement of SOX9 and ACAN

TA Karlsen, RB Jakobsen, TS Mikkelsen… - Stem cells and …, 2014 - liebertpub.com
Lesions of articular cartilage do not heal spontaneously. One treatment strategy would be to
make cartilage in the laboratory by directed chondrogenic differentiation of mesenchymal …

Multi-pathway protective effects of microRNAs on human chondrocytes in an in vitro model of osteoarthritis

RN Al-Modawi, JE Brinchmann, TA Karlsen - Molecular Therapy-Nucleic …, 2019 - cell.com
Osteoarthritis (OA) is the most common degenerative joint disease. One of the main
pathogenic factors of OA is thought to be inflammation. Other factors associated with OA are …

Injectable gelatin/glucosamine cryogel microbeads as scaffolds for chondrocyte delivery in cartilage tissue engineering

YH Huang, HA Chen, CH Chen, HT Liao… - International Journal of …, 2023 - Elsevier
In this study, we fabricate squeezable cryogel microbeads as injectable scaffolds for
minimum invasive delivery of chondrocytes for cartilage tissue engineering applications. The …

A 3D‐printed PLCL scaffold coated with collagen type i and its biocompatibility

Y He, W Liu, L Guan, J Chen, L Duan… - BioMed research …, 2018 - Wiley Online Library
Scaffolds play an important role in tissue engineering and their structure and
biocompatibility have great influence on cell behaviors. In this study, poly (l‐lactide‐co‐ε …