Surface engineering and patterning using parylene for biological applications

CP Tan, HG Craighead - Materials, 2010 - mdpi.com
Parylene is a family of chemically vapour deposited polymer with material properties that are
attractive for biomedicine and nanobiotechnology. Chemically inert parylene “peel-off” …

Biophysical properties of nucleic acids at surfaces relevant to microarray performance

AN Rao, DW Grainger - Biomaterials science, 2014 - pubs.rsc.org
Both clinical and analytical metrics produced by microarray-based assay technology have
recognized problems in reproducibility, reliability and analytical sensitivity. These issues are …

Optofluidic sensing from inkjet-printed droplets: the enormous enhancement by evaporation-induced spontaneous flow on photonic crystal biosilica

X Kong, Y Xi, P LeDuff, E Li, Y Liu, LJ Cheng… - Nanoscale, 2016 - pubs.rsc.org
Novel transducers for detecting an ultra-small volume of an analyte solution play pivotal
roles in many applications such as chemical analysis, environmental protection and …

Nanoscale resolution, multicomponent biomolecular arrays generated by aligned printing with parylene peel-off

CP Tan, BR Cipriany, DM Lin, HG Craighead - Nano letters, 2010 - ACS Publications
We present “Print-and-Peel”, a high-throughput method to generate multicomponent
biomolecular arrays with sub-100 nm nanoscale feature width. An inkjet printer is first …

Parylene peel-off arrays to probe the role of cell–cell interactions in tumour angiogenesis

CP Tan, B Ri Seo, DJ Brooks, EM Chandler… - Integrative …, 2009 - academic.oup.com
Microenvironmental conditions impact tumour angiogenesis, but the role of cell–cell
interactions in modulating the angiogenic capability of tumour cells is not well understood …

A fluorometric microarray with ZnO substrate-enhanced fluorescence and suppressed “coffee-ring” effects for fluorescence immunoassays

S Li, M Dong, R Li, L Zhang, Y Qiao, Y Jiang, W Qi… - Nanoscale, 2015 - pubs.rsc.org
A glass slide was first patterned with hydrophobic hexadecyltrimethoxysilane (HDS) and
then microspotted with hydrophilic ZnO nanoparticles in an aminopropyltriethoxysilane …

Use of photolithography to encode cell adhesive domains into protein microarrays

JY Lee, SS Shah, CC Zimmer, G Liu, A Revzin - Langmuir, 2008 - ACS Publications
Protein microarrays are rapidly emerging as valuable tools in creating combinatorial cell
culture systems where inducers of cellular differentiation can be identified in a rapid and …

Protein microarray spots are modulated by patterning method, surface chemistry and processing conditions

KFA Clancy, S Dery, V Laforte, P Shetty… - Biosensors and …, 2019 - Elsevier
The uniformity of the protein patterns, their shape, and the contrast between the
fluorescence signal of the pattern and the background, critically modulate the quantitative …

Suppressing the ring stain effect with superhydrophilic/superhydrophobic patterned surfaces

Q Yin, F Sun, X Wang, S Gao, S Zhang, J Qi… - ACS …, 2020 - ACS Publications
The ring stain phenomenon is a critical hindrance to the distribution of the solute during
drying for biochemical assays and materials deposition. Herein, we developed a substrate …

Spatially Addressable Multiplex Biodetection by Calibrated Micro/Nanostructured Surfaces

S Dobroiu, FC van Delft, A Sudalaiyadum Perumal… - ACS …, 2023 - ACS Publications
A challenge of any biosensing technology is the detection of very low concentrations of
analytes. The fluorescence interference contrast (FLIC) technique improves the fluorescence …