While behavioral interventions remain the mainstay of treatment of autism spectrum disorder
(ASD), several potential targeted treatments addressing the underlying neurophysiology of …

Fragile X syndrome (FXS) is the leading inherited form of intellectual disability and autism
spectrum disorder, and patients can present with severe behavioural alterations, including …

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by the full mutation as
well as highly localized methylation of the fragile X mental retardation 1 (FMR1) gene on the …

Rationale: Mitochondrial dysfunction and oxidative stress occur in vascular dementia (VaD),
but the specific molecular mechanism regulating these events remains unclear. Peroxisome …

Metformin as a first-line drug for type 2 diabetes mellitus (T2DM) treatment is widely studied.
Metformin can reduce liver glucose output and improve insulin resistance. Recent evidence …

The prevalence of somatic insulinopathies, like metabolic syndrome (MetS), obesity, and
type 2 diabetes mellitus (T2DM), is higher in Alzheimer's disease (AD), autism spectrum …

Although circadian and sleep disorders are frequently associated with autism spectrum
disorders (ASD), it remains elusive whether clock gene disruption can lead to autistic-like …

Circadian clocks regulate much of behavior and physiology, but the mechanisms by which
they do so remain poorly understood. While cyclic gene expression is thought to underlie …

Metformin is a first-line drug for treating type 2 diabetes mellitus (T2DM) and one of the most
commonly prescribed drugs in the world. Besides its hypoglycemic effects, metformin also …

RNA-binding proteins (RBPs) acting at various steps in the post-transcriptional regulation of
gene expression play crucial roles in neuronal development and synaptic plasticity. Genetic …