Synergy between amyloid-β and tau in Alzheimer's disease
Patients with Alzheimer's disease (AD) present with both extracellular amyloid-β (Aβ)
plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years …
plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years …
Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies
G Limorenko, HA Lashuel - Chemical Society Reviews, 2022 - pubs.rsc.org
Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease
Alzheimer's disease (AD) causes unrelenting, progressive cognitive impairments, but its
course is heterogeneous, with a broad range of rates of cognitive decline. The spread of tau …
course is heterogeneous, with a broad range of rates of cognitive decline. The spread of tau …
[HTML][HTML] Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology
SH Lee, WJ Meilandt, L Xie, VD Gandham, H Ngu… - Neuron, 2021 - cell.com
Loss-of-function TREM2 mutations strongly increase Alzheimer's disease (AD) risk. Trem2
deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a …
deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a …
Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
JW Vogel, Y Iturria-Medina, OT Strandberg… - Nature …, 2020 - nature.com
Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that
tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (A β). We …
tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (A β). We …
Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
Z He, JL Guo, JD McBride, S Narasimhan, H Kim… - Nature medicine, 2018 - nature.com
Alzheimer's disease (AD) is characterized by extracellular amyloid-β (Aβ) plaques and
intracellular tau inclusions. However, the exact mechanistic link between these two AD …
intracellular tau inclusions. However, the exact mechanistic link between these two AD …
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo
The coexistence of amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the neocortex is
linked to neural system failure and cognitive decline in Alzheimer's disease. However, the …
linked to neural system failure and cognitive decline in Alzheimer's disease. However, the …
Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease
N Mattsson-Carlgren, E Andersson, S Janelidze… - Science …, 2020 - science.org
The links between β-amyloid (Aβ) and tau in Alzheimer's disease are unclear. Cognitively
unimpaired persons with signs of Aβ pathology had increased cerebrospinal fluid (CSF) …
unimpaired persons with signs of Aβ pathology had increased cerebrospinal fluid (CSF) …
In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease
Both the replication of protein aggregates and their spreading throughout the brain are
implicated in the progression of Alzheimer's disease (AD). However, the rates of these …
implicated in the progression of Alzheimer's disease (AD). However, the rates of these …
Activated microglia mitigate Aβ-associated tau seeding and spreading
In Alzheimer's disease (AD) models, AD risk variants in the microglial-expressed TREM2
gene decrease Aβ plaque–associated microgliosis and increase neuritic dystrophy as well …
gene decrease Aβ plaque–associated microgliosis and increase neuritic dystrophy as well …