CDH2 belongs to the classic cadherin family of Ca2+-dependent cell adhesion molecules
with a meticulously described dual role in cell adhesion and β-catenin signaling. During …

NF-Y is a conserved sequence-specific trimeric Transcription Factor-TF-binding to the
CCAAT element. We review here the role (s) in development, from pre-implantation embryo …

The current dogma of HD pathoetiology posits it is a degenerative disease affecting primarily
the striatum, caused by a gain of function (toxicity) of the mutant mHTT that kills neurons …

The cerebellum is crucial for both motor and nonmotor functions. Alzheimer's disease (AD),
alongside other dementias such as vascular dementia (VaD), Lewy body dementia (DLB) …

Protein phosphorylation plays a role in many important cellular functions such as cellular
plasticity, gene expression, and intracellular trafficking. All of these are dysregulated in …

Huntington's disease (HD) is caused by an aberrant expansion of CAG repeats in the HTT
gene that mainly affects basal ganglia. Although striatal dysfunction has been widely studied …

While Huntington disease (HD) is caused solely by a polyglutamine expansion in the
huntingtin gene, environmental factors can influence HD onset and progression. Here, we …

Background The dystonias are a heterogeneous group of hyperkinetic disorders
characterized by sustained or intermittent muscle contractions that cause abnormal …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease
characterized by a late clinical onset of psychiatric, cognitive, and motor symptoms …

DNA repeat expansion disorders are a group of neuromuscular and neurodegenerative
diseases that arise from the inheritance of long tracts of nucleotide repetitions, located in the …