Diverse PFAS produce unique transcriptomic changes linked to developmental toxicity in zebrafish
Per-and polyfluoroalkyl substances (PFAS) are a widespread and persistent class of
contaminants posing significant environmental and human health concerns. Comprehensive …
contaminants posing significant environmental and human health concerns. Comprehensive …
Comparative Proteomics Highlights that GenX Exposure Leads to Metabolic Defects and Inflammation in Astrocytes
Exposure to PFAS such as GenX (HFPO dimer acid) has become increasingly common due
to the replacement of older generation PFAS in manufacturing processes. While …
to the replacement of older generation PFAS in manufacturing processes. While …
Association of adverse fetal outcomes with placental inflammation after oral gestational exposure to hexafluoropropylene oxide dimer acid (GenX) in Sprague-Dawley …
D Lv, H Liu, Q An, C Lei, Y Wang, J Sun, C Li… - Journal of Hazardous …, 2024 - Elsevier
Hexafluoropropylene oxide dimer acid (HFPO-DA), known as “GenX” for its trade name, is
gradually taking the place of Perfluorooctanoic acid (PFOA). However, there is a poor …
gradually taking the place of Perfluorooctanoic acid (PFOA). However, there is a poor …
Thyroid disrupting effects and the developmental toxicity of hexafluoropropylene oxide oligomer acids in zebrafish during early development
X Zhao, X Meng, D Yang, S Dong, J Xu, D Chen, Y Shi… - Chemosphere, 2024 - Elsevier
As perfluorooctanoic acid (PFOA) alternatives, hexafluoropropylene oxide dimeric acid
(HFPO-DA) and hexafluoropropylene oxide trimeric acid (HFPO-TA) have been increasingly …
(HFPO-DA) and hexafluoropropylene oxide trimeric acid (HFPO-TA) have been increasingly …
[HTML][HTML] Locomotion and brain gene expression exhibit sex-specific non-monotonic dose-response to HFPO-DA during Drosophila melanogaster lifespan
Background Legacy per-and polyfluoroalkyl substances (PFAS), known for their
environmental persistence and bio-accumulative properties, have been phased out in the …
environmental persistence and bio-accumulative properties, have been phased out in the …
Investigating the applicability domain of the hiPSC-based PluriLum assay: an embryotoxicity assessment of chemicals and drugs
To meet the growing demand for developmental toxicity assessment of chemicals, New
Approach Methodologies (NAMs) are needed. Previously, we developed two 3D in vitro …
Approach Methodologies (NAMs) are needed. Previously, we developed two 3D in vitro …
Metabolomic changes following GenX and PFBS exposure in developing zebrafish
F Dunn, SE Paquette, KD Pennell, JS Plavicki… - Aquatic Toxicology, 2024 - Elsevier
Short chain per-and polyfluoroalkyl substances (PFAS), including hexafluoropropylene
oxide dimer acid (GenX) and perfluorobutane sulfonate (PFBS), are replacement chemicals …
oxide dimer acid (GenX) and perfluorobutane sulfonate (PFBS), are replacement chemicals …
[引用][C] Identification of biomarkers of the retinoic acid signaling pathway in the zebrafish embryo model to predict human developmental toxicants
LMEM Samrani - 2023 - Utrecht University