Enantiomers, where chirality arises from restricted rotation around a single bond, are
atropisomers. Due to the unique nature of the origins of their chirality, synthetic strategies to …

Conspectus Aromatic structures are widespread motifs throughout organic chemistry, and C–
H activation has been recognized as a major tool for enabling their sustainable and efficient …

The synthesis of organic compounds efficiently via fewer steps but in higher yields is
desirable as this reduces energy and reagent use, waste production, and thus …

Protonation of C–M bonds and its microscopic reverse, metalation of C–H bonds, are
fundamental steps in a variety of metal-catalyzed processes. As such, studies on protonation …

Conspectus Conversion of common reactants to diverse products is a key objective of
organic syntheses. Recent developments in transition-metal-catalyzed C–H functionalization …

Pd-catalysed C–H functionalisation of free carboxylic acids has drawn significant attention
over the last few years due to the predominance of carboxylic acid moieties in …

This review summarizes the state-of-the-art in transition metal-catalyzed asymmetric
alkylation of heteroarenes using alkenes (covering literature from 2000 to late 2021). Based …

The direct functionalization of C− H bonds is among the most fundamental chemical
transformations in organic synthesis. However, when the innate reactivity of the substrate …

The direct, catalytic arylation of simple arenes in small excess with aryl bromides is
disclosed. The developed method does not require the assistance of directing groups and …

We report a direct tandem C–O/C–H activation approach to C–C bond formation using
palladium catalysis. This reaction combines C–O oxidative addition at enol pivalates with …