In this" Critical Review" we made a historical introduction of drugs assayed against Chagas
disease beginning in 1912 with the works of Mayer and Rocha Lima up to the experimental …

The more significant bioactivities of a variety of semicarbazones (anti-protozoa,
anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and …

American trypanosomiasis, or Chagas' disease, is the leading cause of heart disease in
Latin America. Currently there is an urgent need to develop antitrypanosomal therapy due to …

A new ligand, 2-oxo-1, 2-dihydroquinoline-3-carbaldehyde semicarbazone (OQsc-H)(1);, its
N (4)-phenyl derivative (OQsc-Ph)(2); and their corresponding copper (II) complexes [CuCl2 …

Chagas disease and African sleeping sickness are trypanosomal infections that represent
important public health problems in Latin America and Africa, respectively. The restriction of …

As a contribution to the development of novel vanadium complexes with pharmacologically
interesting moieties, new dioxovanadium (V) semicarbazone complexes with the formula cis …

This article shows that thiosemicarbazones, semicarbazones and their metal complexes can
exhibit target selectivity along with a wide pharmacological profile. Complexes of …

It has been over a century since Carlos Chagas discovered the Trypanosoma cruzi (T. cruzi)
as the causative agent of Chagas disease (CD), a neglected tropical disease with several …

Chagas' disease is a major parasitic problem in developing countries in Central and South
America. Chemotherapy for such disease is still insufficient and not effective in its chronic …

Fused diaza-heterocycles constitute the core structure of numerous bioactive natural
products and effective therapeutic drugs. Among them, phthalazines have been recognized …