Inflammatory process in Alzheimer's and Parkinson's diseases: central role of cytokines

Q Alam, M Zubair Alam, G Mushtaq… - Current …, 2016 - ingentaconnect.com
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most widespread
neurological disorders (NDs) characterized by degeneration of cognitive and motor …

Cytokine gene polymorphism in human disease: on-line databases

J Bidwell, L Keen, G Gallagher, R Kimberly… - Genes & …, 1999 - nature.com
The pathologies of many infectious, autoimmune and malignant diseases are influenced by
the profiles of cytokine production in pro-inflammatory (TH1) and anti-inflammatory (TH2) T …

Transforming growth factor β and atherosclerosis: so far, so good for the protective cytokine hypothesis

DJ Grainger - Arteriosclerosis, thrombosis, and vascular biology, 2004 - Am Heart Assoc
The role of the anti-inflammatory cytokine transforming growth factor β (TGF-β) in
atherosclerosis has been the subject of considerable debate for a decade. In the early …

A Transforming Growth Factorβ1 Signal Peptide Variant Increases Secretion in Vitro and Is Associated with Increased Incidence of Invasive Breast Cancer

AM Dunning, PD Ellis, S McBride, HL Kirschenlohr… - Cancer research, 2003 - AACR
There is evidence that transforming growth factor (TGF) β acts as a suppressor of tumor
initiation but also as a promoter of tumor progression when the antiproliferative effect of the …

Association of a T29→ C polymorphism of the transforming growth factor-β1 gene with genetic susceptibility to myocardial infarction in Japanese

M Yokota, S Ichihara, TL Lin, N Nakashima… - Circulation, 2000 - Am Heart Assoc
Background—Transforming growth factor-β (TGF-β) is an important regulator of vascular
remodeling and is involved in the pathogenesis of atherosclerosis. AT→ C transition at …

Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease

A Kinoshita, T Saito, H Tomita, Y Makita, K Yoshida… - Nature …, 2000 - nature.com
Abstract Camurati-Engelmann disease (CED, MIM 131300) is an autosomal dominant,
progressive diaphyseal dysplasia characterized by hyperosteosis and sclerosis of the …

TGF-β1 functional polymorphisms: a review

GCM Cebinelli, KP Trugilo, SB Garcia… - European cytokine …, 2016 - Springer
Abstract Transforming Growth Factor β (TGF-β) is a multifunctional cytokine that plays a role
in several biological processes. TGF-β 1 is the most abundantly expressed isoform …

Isothermal whole genome amplification from single and small numbers of cells: a new era for preimplantation genetic diagnosis of inherited disease

AH Handyside, MD Robinson… - Molecular human …, 2004 - academic.oup.com
Preimplantation genetic diagnosis (PGD) of single gene defects following assisted
conception typically involves removal of single cells from preimplantation embryos and …

TGF-β and atherosclerosis in man

DJ Grainger - Cardiovascular research, 2007 - academic.oup.com
The transforming growth factor type-β (TGF-β) superfamily of ligands, receptors, binding
proteins and ligand traps together plays a key role in the maintenance of normal blood …

Transforming growth factor-β1 genotype and susceptibility to chronic obstructive pulmonary disease

L Wu, J Chau, RP Young, V Pokorny… - Journal of Medical …, 2004 - jmg.bmj.com
Background: Only a few long term smokers develop symptomatic chronic obstructive
pulmonary disease (COPD) and this may be due, at least in part, to genetic susceptibility to …