Biomarkers are indispensable to the development of new tuberculosis therapeutics and
vaccines. The most robust biomarkers measure factors that are essential to the underlying …

Tuberculosis is out of control in developing countries, where it is killing millions of people
every year. In these areas, the present vaccine—Mycobacterium bovis bacillus Calmette …

Background The exact role of neutrophils in the pathogenesis of TB is poorly understood.
Recent evidence suggests that neutrophils are not simply scavenging phagocytes in …

Calcidiol, the major circulating metabolite of vitamin D, supports induction of pleiotropic
antimicrobial responses in vitro. Vitamin D supplementation elevates circulating calcidiol …

Interrupting transmission events is critical to tuberculosis control. Cough-generated aerosol
cultures predict tuberculosis transmission better than microbiological or clinical markers. We …

The impact of intestinal helminth infection on Mycobacterium tuberculosis (MTB)-specific
immune responses during active tuberculosis (TB) is not known. We investigated the role of …

Active tuberculosis (TB) is associated with prolonged suppression of Mycobacterium
tuberculosis (MTB)-specific immune responses, but mechanisms involved are understood …

Human neutrophils form extracellular traps during M. tuberculosis infection, but a similar
phenomenon has not been reported in human macrophages. Here we demonstrate that M …

New drugs, vaccines, and other therapies will be required to realise the goal of global
tuberculosis elimination or control. This Review covers the important role biomarkers can …

There is a strong relationship between metabolic state and susceptibility to Mycobacterium
tuberculosis (MTB) infection, with energy metabolism setting the basis for an exaggerated …