A review of exosomal isolation methods: is size exclusion chromatography the best option?

K Sidhom, PO Obi, A Saleem - International journal of molecular sciences, 2020 - mdpi.com
Extracellular vesicles (EVs) are membranous vesicles secreted by both prokaryotic and
eukaryotic cells and play a vital role in intercellular communication. EVs are classified into …

Basic and therapeutic aspects of angiogenesis updated

G Eelen, L Treps, X Li, P Carmeliet - Circulation research, 2020 - Am Heart Assoc
All organisms growing beyond the oxygen diffusion limit critically depend on a functional
vasculature for survival. Yet blood vessels are far more than passive, uniform conduits for …

Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration

DH Ha, H Kim, J Lee, HH Kwon, GH Park, SH Yang… - Cells, 2020 - mdpi.com
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …

Advances in therapeutic applications of extracellular vesicles

OPB Wiklander, MÁ Brennan, J Lötvall… - Science translational …, 2019 - science.org
Extracellular vesicles (EVs) are nanometer-sized, lipid membrane–enclosed vesicles
secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid …

Extracellular vesicles in cancer—implications for future improvements in cancer care

R Xu, A Rai, M Chen, W Suwakulsiri… - Nature reviews Clinical …, 2018 - nature.com
The sustained growth, invasion, and metastasis of cancer cells depend upon bidirectional
cell–cell communication within complex tissue environments. Such communication …

Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications

KW Witwer, BWM Van Balkom, S Bruno… - Journal of …, 2019 - Taylor & Francis
Small extracellular vesicles (sEVs) from mesenchymal stromal/stem cells (MSCs) are
transiting rapidly towards clinical applications. However, discrepancies and controversies …

Stem cell-derived exosomes as nanotherapeutics for autoimmune and neurodegenerative disorders

M Riazifar, MR Mohammadi, EJ Pone, A Yeri… - ACS …, 2019 - ACS Publications
To dissect therapeutic mechanisms of transplanted stem cells and develop exosome-based
nanotherapeutics in treating autoimmune and neurodegenerative diseases, we assessed …

Exosomes—beyond stem cells for restorative therapy in stroke and neurological injury

ZG Zhang, B Buller, M Chopp - Nature Reviews Neurology, 2019 - nature.com
Stroke is a leading cause of disability worldwide, and brain injuries devastate patients and
their families, but currently no drugs on the market promote neurological recovery. Limited …

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the …

C Théry, KW Witwer, E Aikawa… - Journal of …, 2018 - Wiley Online Library
The last decade has seen a sharp increase in the number of scientific publications
describing physiological and pathological functions of extracellular vesicles (EVs), a …

MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

S Zhang, SJ Chuah, RC Lai, JHP Hui, SK Lim, WS Toh - Biomaterials, 2018 - Elsevier
Mesenchymal stem cell (MSC) exosome was previously shown to be effective in repairing
critical size osteochondral defects in an immunocompetent rat model. Here we investigate …