Pyrimidines are aromatic heterocyclic compounds that contain two nitrogen atoms at
positions 1 and 3 of the six-membered ring. Numerous natural and synthetic pyrimidines are …

Heterocyclic derivatives as a major group of organic compounds are enormously used for a
wide range of pharmaceutical and industrial applications. They are known for their biological …

Cyclooxygenase-2 is a very important physiological enzyme playing key roles in various
biological functions especially in the mechanism of pain and inflammation, among other …

Most of the anti-inflammatory drugs in clinical practice are becoming outdated owing to their
potential side and adverse effects. These are found to be highly unsafe for long term use …

Novel differently substituted pyrazole derivatives were designed, synthesized and evaluated
for their anticancer activity. All compounds selectively inhibited COX-2 enzyme (IC 50 …

Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they
constitute an important class of natural and synthetic compounds exhibiting diverse useful …

Promising inhibitory activities of the parasite multiplication were obtained upon evaluation of
in vivo antimalarial activities of new pyrazolylpyrazoline derivatives against Plasmodium …

New thiophene and annulated thiophene pyrazole hybrids were synthesized and screened
for their in vitro COX-1/COX-2 enzymatic inhibition and in vivo anti-inflammatory activities. All …

Pyrimidine itself or in different fused forms is an important chemical motif for every step of
cell life. Alongside, it exists as a key pharmacophoric part in thiamine, alloxan, orotic acid …

Thiazolidinones are pharmacologically active compounds, extensively used as a precursor
for obtaining versatile molecules with several biological activities including anti-microbial …