The use of isotretinoin for acne–an update on optimal dosing, surveillance, and adverse effects

E Bagatin, CS Costa - Expert review of clinical pharmacology, 2020 - Taylor & Francis
Introduction Acne is a chronic, inflammatory, and immune mediated disease of
pilosebaceous unit, highly prevalent in adolescents. It involves face, trunk, and back; may …

Adverse events in isotretinoin therapy: a single-arm meta-analysis

J Kapała, J Lewandowska, W Placek… - International journal of …, 2022 - mdpi.com
Isotretinoin (ISO) is an oral prescription-only retinoid, well known for its acne-treating effect.
However, it affects a substantial number of human cell types, causing a broad spectrum of …

Treatment challenges in adult female acne and future directions

E Bagatin, MAD Rocha, THP Freitas… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Acne is a chronic, inflammatory, and immune-mediated disease of the
pilosebaceous unit, highly prevalent in adolescents. However, an increasing number of …

The impact of isotretinoin on the pituitary-ovarian axis: An interpretative review of the literature

A Abdelhamed, RE El-Dawla, AS Karadag… - Reproductive …, 2021 - Elsevier
Abstract Isotretinoin (13-cis-retinoic acid), a derivative of vitamin A, is used in the treatment
of severe acne resulting in sebum suppression induced by sebocyte apoptosis. Isotretinoin …

The effect of systemic isotretinoin on male fertility

L Çinar, D Kartal, C Ergin, H Aksoy… - Cutaneous and …, 2016 - Taylor & Francis
Background/objective: Acne vulgaris is one of the most common diseases of the youth.
Systemic isotretinoin is the only drug which acts on all of the etiopathogenic mechanisms of …

The impact of oral isotretinoin on ovarian functions of acne patients complaining of polycystic ovarian syndrome: a prospective study

HI Elnagar, OA Hashem, HO Aboelwafa… - Journal of Ovarian …, 2024 - Springer
Background Women have polycystic ovarian syndrome (PCOS) at higher rates than any
other endocrine condition with an average incidence rate of 6 to 8%. Acne is an immune …

Exploring the association between isotretinoin and sexual dysfunction: a comprehensive scoping review

E Tan, H Kennedy, M Rademaker - Clinical and Experimental …, 2024 - academic.oup.com
Background A potential link between isotretinoin and sexual dysfunction has been reported
in various studies. However, such an association has not been explored within the context of …

The effect of isotretinoin on ovarian reserve based on hormonal parameters, ovarian volume, and antral follicle count in women with acne

H Aksoy, L Cinar, G Acmaz, U Aksoy, T Aydin… - Gynecologic and …, 2015 - karger.com
Abstract Backgroud/Aims: Widely prescribed in routine practice, isotretinoin has an unknown
impact on ovarian reserve. With a long history in acne treatment and numerous potential …

Long-term effect of systemic isotretinoin on female fertility

SL Cinar, D Kartal, H Aksoy, E Cinar… - … and ocular toxicology, 2017 - Taylor & Francis
Background/objective: Acne vulgaris is one of the most common diseases of the youth.
Systemic isotretinoin is the only drug which acts on all of the etiopathogenic mechanisms of …

Perceptions about oral isotretinoin treatment

B Tugrul Ayanoglu, HG Demirdag… - Dermatologic …, 2019 - Wiley Online Library
There are some studies on the knowledge, beliefs, and perceptions of patients about acne
vulgaris, however, there is no sufficient data on patients' beliefs about oral isotretinoin …