[HTML][HTML] A lifelong duty: how Xist maintains the inactive X chromosome
Female eutherians transcriptionally silence one X chromosome to balance gene dosage
between the sexes. X-chromosome inactivation (XCI) is initiated by the lncRNA Xist, which …
between the sexes. X-chromosome inactivation (XCI) is initiated by the lncRNA Xist, which …
Compensation of gene dosage on the mammalian X
Changes in gene dosage can have tremendous evolutionary potential (eg whole-genome
duplications), but without compensatory mechanisms, they can also lead to gene …
duplications), but without compensatory mechanisms, they can also lead to gene …
RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals
In mammals, X-chromosomal genes are expressed from a single copy since males (XY)
possess a single X chromosome, while females (XX) undergo X inactivation. To compensate …
possess a single X chromosome, while females (XX) undergo X inactivation. To compensate …
Incomplete transcriptional dosage compensation of chicken and platypus sex chromosomes is balanced by post-transcriptional compensation
Heteromorphic sex chromosomes (XY or ZW) present problems of gene dosage imbalance
between sexes and with autosomes. A need for dosage compensation has long been …
between sexes and with autosomes. A need for dosage compensation has long been …
Establishing the Link between X-Chromosome Aberrations and TP53 Status, with Breast Cancer Patient Outcomes
Ubiquitous to normal female human somatic cells, X-chromosome inactivation (XCI) tightly
regulates the transcriptional silencing of a single X chromosome from each pair. Some …
regulates the transcriptional silencing of a single X chromosome from each pair. Some …
Transposon wave remodeled the epigenomic landscape in the rapid evolution of X-Chromosome dosage compensation
DCH Metzger, I Porter, B Mobley, BA Sandkam… - Genome …, 2023 - genome.cshlp.org
Sex chromosome dosage compensation is a model to understand the coordinated evolution
of transcription; however, the advanced age of the sex chromosomes in model systems …
of transcription; however, the advanced age of the sex chromosomes in model systems …
Controlled X‐chromosome dynamics defines meiotic potential of female mouse in vitro germ cells
The mammalian germline is characterized by extensive epigenetic reprogramming during its
development into functional eggs and sperm. Specifically, the epigenome requires resetting …
development into functional eggs and sperm. Specifically, the epigenome requires resetting …
Appropriate glycemic management protects the germline but not the uterine environment in hyperglycemia
Emerging evidence indicates that parental diseases can impact the health of subsequent
generations through epigenetic inheritance. Recently, it was shown that maternal diabetes …
generations through epigenetic inheritance. Recently, it was shown that maternal diabetes …
A landscape of X-inactivation during human T cell development
B Gylemo, M Bensberg, V Hennings… - Nature …, 2024 - nature.com
Females exhibit a more robust immune response to both self-antigens and non-self-antigens
than males, resulting in a higher prevalence of autoimmune diseases but more effective …
than males, resulting in a higher prevalence of autoimmune diseases but more effective …
Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows
The evolution of genetic sex determination is often accompanied by degradation of the sex-
limited chromosome. Male heterogametic systems have evolved convergent, epigenetic …
limited chromosome. Male heterogametic systems have evolved convergent, epigenetic …