The role of nanotechnology in the treatment of viral infections

L Singh, HG Kruger, GEM Maguire… - Therapeutic …, 2017 - journals.sagepub.com
Infectious diseases are the leading cause of mortality worldwide, with viruses in particular
making global impact on healthcare and socioeconomic development. In addition, the rapid …

The interplay between adeno-associated virus and its helper viruses

AF Meier, C Fraefel, M Seyffert - Viruses, 2020 - mdpi.com
The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on
helper factors to replicate. Those helper factors can be provided by coinfecting helper …

ViralZone: a knowledge resource to understand virus diversity

C Hulo, E De Castro, P Masson… - Nucleic acids …, 2011 - academic.oup.com
The molecular diversity of viruses complicates the interpretation of viral genomic and
proteomic data. To make sense of viral gene functions, investigators must be familiar with …

Evolution and diversity in human herpes simplex virus genomes

ML Szpara, D Gatherer, A Ochoa, B Greenbaum… - Journal of …, 2014 - Am Soc Microbiol
ABSTRACT Herpes simplex virus 1 (HSV-1) causes a chronic, lifelong infection in> 60% of
adults. Multiple recent vaccine trials have failed, with viral diversity likely contributing to …

From ancient to emerging infections: the odyssey of viruses in the male genital tract

A Le Tortorec, G Matusali, D Mahé… - Physiological …, 2020 - journals.physiology.org
The male genital tract (MGT) is the target of a number of viral infections that can have
deleterious consequences at the individual, offspring, and population levels. These …

Examining the role of EGR1 during viral infections

CM Woodson, K Kehn-Hall - Frontiers in Microbiology, 2022 - frontiersin.org
Early growth response 1 (EGR1) is a multifunctional mammalian transcription factor capable
of both enhancing and/or inhibiting gene expression. EGR1 can be activated by a wide array …

Cellular state landscape and herpes simplex virus type 1 infection progression are connected

MK Pietilä, JJ Bachmann, J Ravantti… - Nature …, 2023 - nature.com
Prediction, prevention and treatment of virus infections require understanding of cell-to-cell
variability that leads to heterogenous disease outcomes, but the source of this heterogeneity …

VEGF-A expression by HSV-1–infected cells drives corneal lymphangiogenesis

TR Wuest, DJJ Carr - Journal of Experimental Medicine, 2010 - rupress.org
Inflammatory lymphangiogenesis plays a crucial role in the development of inflammation
and transplant rejection. The mechanisms of inflammatory lymphangiogenesis during …

Viral infections and male infertility: a comprehensive review of the role of oxidative stress

RE Akhigbe, S Dutta, MA Hamed, AF Ajayi… - … in Reproductive Health, 2022 - frontiersin.org
Viral infections have been a part of human existence to date, though viruses have posed a
huge threat with various outbreaks lately. These threats are associated with reproductive …

Herpes simplex virus 1 (HSV-1) for cancer treatment

Y Shen, J Nemunaitis - Cancer gene therapy, 2006 - nature.com
Cancer remains a serious threat to human health, causing over 500 000 deaths each year in
US alone, exceeded only by heart diseases. Many new technologies are being developed to …