Post-translational modifications (PTMs) generate marginally modified isoforms of native
peptides, proteins and lipoproteins thereby regulating protein functions, molecular …

Protein phosphorylation is a post-translational modification (PTM) that orchestrates a diverse
array of cellular processes. Because this modification serves as a rapid and reversible …

Mass spectrometry (MS)–based high-throughput proteomics is the core technique for large-
scale protein characterization. Due to the extreme complexity of proteomes, sophisticated …

Isobaric mass tag-based quantitative proteomics strategies such as iTRAQ and TMT utilize
reporter ions in the low mass range of tandem MS spectra for relative quantification. The …

Metabolomics and exposomics are important in the studies of human health and diseases.
Chemical isotope labeling (CIL) combined with mass spectrometry (MS) can not only …

Mass spectrometry-based proteomics has considerably extended our knowledge about the
occurrence and dynamics of protein post-translational modifications (PTMs). So far …

Multiplex isobaric tags (eg, tandem mass tags (TMT) and isobaric tags for relative and
absolute quantification (iTRAQ)) are a valuable tool for high-throughput mass spectrometry …

Urinary proteomics has become one of the most attractive topics in disease biomarker
discovery. MS‐based proteomic analysis has advanced continuously and emerged as a …

Mitochondrial dysfunction is associated with many human diseases, including cancer and
neurodegeneration, that are often linked to proteins and pathways that are not well …

More than 130 years ago, it was recognized that platelets are key mediators of hemostasis.
Nowadays, it is established that platelets participate in additional physiological processes …