Genetic engineering as a strategy to improve the therapeutic efficacy of mesenchymal stem/stromal cells in regenerative medicine

PKF Damasceno, TSA De Santana… - Frontiers in Cell and …, 2020 - frontiersin.org
Mesenchymal stem/stromal cells (MSCs) have been widely studied in the field of
regenerative medicine for applications in the treatment of several disease settings. The …

HOX genes in stem cells: Maintaining cellular identity and regulation of differentiation

J Steens, D Klein - Frontiers in cell and developmental biology, 2022 - frontiersin.org
Stem cells display a unique cell type within the body that has the capacity to self-renew and
differentiate into specialized cell types. Compared to pluripotent stem cells, adult stem cells …

Single‐cell and spatial transcriptomics decodes Wharton's jelly‐derived mesenchymal stem cells heterogeneity and a subpopulation with wound repair signatures

P Chen, S Tang, M Li, D Wang, C Chen… - Advanced …, 2023 - Wiley Online Library
The highly heterogeneous characteristics of Wharton's jelly mesenchymal stem cells (WJ‐
MSCs) may be responsible for the poor clinical outcomes and poor reproducibility of …

Improving mesenchymal stem/stromal cell potency and survival: Proceedings from the International Society of Cell Therapy (ISCT) MSC preconference held in May …

JA Nolta, J Galipeau, DG Phinney - Cytotherapy, 2020 - Elsevier
As part of the International Society of Cell Therapy (ISCT) 2018 Annual Meeting, the
Mesenchymal Stem/Stromal Cell (MSC) committee organized a pre-conference, which …

Liver disease and cell therapy: advances made and remaining challenges

S Khan, S Mahgoub, N Fallatah, PF Lalor… - Stem Cells, 2023 - academic.oup.com
The limited availability of organs for liver transplantation, the ultimate curative treatment for
end stage liver disease, has resulted in a growing and unmet need for alternative therapies …

Arming mesenchymal stromal/stem cells against cancer: has the time come?

G Golinelli, I Mastrolia, B Aramini, V Masciale… - Frontiers in …, 2020 - frontiersin.org
Since mesenchymal stromal/stem cells (MSCs) were discovered, researchers have been
drawn to study their peculiar biological features, including their immune privileged status …

Multiple roles of HOX proteins in Metastasis: Let me count the ways

J Jonkers, P Pai, S Sukumar - Cancer and Metastasis Reviews, 2020 - Springer
Abstract Knowledge of the role of HOX proteins in cancer has been steadily accumulating in
the last 25 years. They are encoded by 39 HOX genes arranged in 4 distinct clusters, and …

Targeting molecular signal transduction pathways in hepatocellular carcinoma and its implications for cancer therapy

IH Mir, S Guha, J Behera… - Cell Biology …, 2021 - Wiley Online Library
Hepatocellular carcinoma is a substantial health concern. It is currently the third dominating
cause of mortality associated with cancer worldwide. The development of hepatocellular …

Non-coding RNAs steering the senescence-related progress, properties, and application of mesenchymal stem cells

J Cai, H Qi, K Yao, Y Yao, D Jing, W Liao… - Frontiers in Cell and …, 2021 - frontiersin.org
The thirst to postpone and even reverse aging progress has never been quenched after all
these decades. Unequivocally, mesenchymal stem cells (MSCs), with extraordinary abilities …

Autologous marrow mesenchymal stem cell driving bone regeneration in a rabbit model of femoral Head Osteonecrosis

I Mastrolia, A Giorgini, A Murgia, P Loschi, T Petrachi… - Pharmaceutics, 2022 - mdpi.com
Osteonecrosis of the femoral head (ONFH) is a progressive degenerative disease that
ultimately requires a total hip replacement. Mesenchymal stromal/stem cells (MSCs) …