During development, neural networks are established in a highly organized manner, which
persists throughout life. Neurotrophins play crucial roles in the developing nervous system …

Neurotrophins are essential for multiple aspects of neuronal development and function.
Especially BDNF (brain-derived-neurotrophic-factor) has been shown to play an important …

In subjects with schizophrenia, impairments in working memory are associated with
dysfunction of the dorsolateral prefrontal cortex (DLPFC). This dysfunction appears to be …

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, modulates
neuronal survival, differentiation, and synaptic function. Reduced BDNF expression in the …

Major depressive disorder (MDD) is a mood disorder that affects behavior and impairs
cognition. A gene potentially important to this disorder is the brain derived neurotrophic …

Dysfunction of inhibitory neurons in the prefrontal cortex (PFC), represented by decreased
expression of GABA-related genes such as the 67 kDa isoform of glutamate decarboxylase …

Recent advances in understanding the role of neurotrophins on activity-dependent plasticity
have provided insight into how behavior can affect specific aspects of neuronal biology. We …

The GABAergic deficit hypothesis of major depressive disorders (MDDs) posits that reduced
γ-aminobutyric acid (GABA) concentration in brain, impaired function of GABAergic …

The mammalian cerebral cortex represents one of the most recent and astonishing
inventions of nature, responsible of a large diversity of functions that range from sensory …

Schizophrenia is a severe mental illness that afflicts nearly 1% of the world's population.
One of the cardinal pathological features of schizophrenia is perturbation in synaptic …