As part of the neurovascular unit, the blood-brain barrier (BBB) is a unique, dynamic
regulatory boundary that limits and regulates the exchange of molecules, ions, and cells …

Although matrix metalloproteinases (MMPs) are implicated in the regulation of numerous
physiological processes, evidence of their pathological roles have also been obtained in the …

Rationale: Mesenchymal stromal cell–based therapy is promising against ischemic heart
failure. However, its efficacy is limited due to low cell retention and poor paracrine function …

Inflammatory damage plays an important role in cerebral ischemic pathogenesis and
represents a new target for treatment of stroke. Berberine is a natural medicine with multiple …

Stroke is a leading cause of death and disability worldwide. However, after years of in-depth
research, the pathophysiology of stroke is still not fully understood. Increasing evidence …

Background Cell-based therapeutic strategies have been proposed as an alternative for
brain repair after stroke, but their clinical application has been hampered by potential …

Nicotinic acetylcholine α7 receptors (α7 nAChRs) have a well-known modulator effect in
neuroinflammation. Yet, the therapeutical effect of α7 nAChRs activation after stroke has …

Stroke is the leading cause of death and the main cause of disability in surviving patients.
The detrimental interaction between immune cells, glial cells, and matrix components in …

The blood–brain barrier (BBB) is a functional phenotype exhibited by the neurovascular unit
(NVU). It is maintained and regulated by the interaction between cellular and non-cellular …

Strokes are the second most common cause of death worldwide and a leading cause of
disability. Regular consumption of polyphenols has been shown to reduce the risk of …