Significant comorbidities between obesity-related metabolic disease and stress-related
psychological disorders suggest important functional interactions between energy balance …

Medicinal plants and their extracts are natural remedies with enormous potential for treating
various diseases, including depression and anxiety. In the case of depression, hundreds of …

In this study we have demonstrated that cyclohexane extract of Hypericum polyanthemum
(POL) and its main phloroglucinol derivative uliginosin B (ULI) present antidepressant-like …

Hypericum polyanthemum, a South Brazilian species showed antidepressant-like and
antinociceptive effects in rodents. Since limited information is available on the toxicity and …

Background Kinin B 1 receptors are inducible molecules up-regulated after inflammatory
stimuli. This study evaluated the relevance of kinin B 1 receptors in a mouse depression …

Pharmacological effects of hydroalcoholic extract prepared from Hypericum origanifolium
Willd.(Guttiferae) on behavioral parameters and pain perceptions of mice were investigated …

The present study was undertaken to investigate the putative activity of a methanol extract of
Hypericum montbretti (Guttiferae) on the central nervous system. Rutin (1519 ppm) and …

Alterations in GABAA receptor expression have been associated with the allopregnanolone
(3α-hydroxy-5α-pregnan-20-one; 3α, 5α-THP) antidepressant-like effect in rats. The present …

Immobility time in the forced swimming has been described as analogous to emotional
blunting or apathy and has been used for characterizing schizophrenia animal models …

It has been described that environmental enrichment (EE) exerts beneficial effects on
cognitive and emotional performances, dendritic branching, synaptic density, neurogenesis …