HIV-1 is completely dependent upon the Env protein to enter cells. The virus typically
replicates in activated CD4+ T cells due to viral entry requirements for the CCR5 coreceptor …

Human immunodeficiency virus type 1 (HIV-1) infection occurs throughout the body and can
have dramatic physical effects, such as neurocognitive impairment in the central nervous …

Genome sequences of transmitted/founder (T/F) HIV-1 have been inferred by analyzing
single genome amplicons of acute infection plasma viral RNA in the context of a …

Defining a macrophage-tropic phenotype for HIV-1 to assess a role in pathogenesis is
complicated by the fact that HIV-1 isolates vary continuously in their ability to enter monocyte …

The chemokine receptor CCR5 has been the focus of intensive studies since its role as a
coreceptor for HIV entry was discovered in 1996. These studies lead to the development of …

It is well established that most new systemic infections of HIV-1 can be traced back to one or
a limited number of founder viruses. Usually, these founders are more closely related to …

In the last three decades, extensive research on human immunodeficiency virus (HIV) has
highlighted its capability to exploit a variety of strategies to enter and infect immune cells …

ABSTRACT HIV-1 is typically CCR5 using (R5) and T cell tropic (T-tropic), targeting memory
CD4+ T cells throughout acute and chronic infections. However, viruses can expand into …

More than 80 million people worldwide have been infected with the human
immunodeficiency virus (HIV). There are now approximately 39 million individuals living with …

Objectives: HIV reservoir in the brain represents a major barrier for curing HIV infection. As
the most abundant, long-lived cell type, astrocytes play a critical role in maintaining the …