Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

The four main types of biomolecules are nucleic acids, proteins, carbohydrates and lipids.
The knowledge about their respective interactions is as important as the individual …

The DNA damage response (DDR) checkpoint is activated when DNA is damaged or when
DNA replication forks stall. The DDR checkpoint plays a critical role in preserving the …

The cell cycle checkpoint kinase Mec1ATR and its integral partner Ddc2ATRIP are vital for
the DNA damage and replication stress response. Mec1–Ddc2 “senses” single-stranded …

The DNA damage response (DDR) is an evolutionarily conserved process essential for cell
survival. The transcription changes triggered by DDR depend on the nature of DNA damage …

R‐loops represent a major source of replication stress, but the mechanism by which these
structures impede fork progression remains unclear. To address this question, we monitored …

Yeast Mec1, and its mammalian ortholog, Ataxia-Telangiectasia and Rad3-related, are giant
protein kinases central to replication stress and double strand DNA break repair. Mec1 ATR …

Nuclear organization has emerged as a critical layer in the coordination of DNA repair
activities. Distinct types of DNA lesions have notably been shown to relocate at the vicinity of …

The preservation of gene expression patterns that define cellular identity throughout the cell
division cycle is essential to perpetuate cellular lineages. However, the progression of cells …

Replication stress is an alteration in the progression of replication forks caused by a variety
of events of endogenous or exogenous origin. In precancerous lesions, this stress is …