Congenital stationary night blindness (CSNB) refers to a group of genetically and clinically
heterogeneous retinal disorders. Seventeen different genes with more than 360 different …

Our robust visual experience is based on the reliable transfer of information from our
photoreceptor cells, the rods and cones, to higher brain centers. At the very first synapse of …

Strategies aimed at invoking synaptic plasticity have therapeutic potential for several
neurological conditions. The human retinal synaptic disease X-linked retinoschisis (XLRS) is …

Expression of channels to specific neuronal sites can critically impact their function and
regulation. Currently, the molecular mechanisms underlying this targeting and intracellular …

Photoreceptor degenerations can trigger morphological alterations in second‐order
neurons, however, the functional implications of such changes are not well known. We …

Sparse neural activity in the dentate gyrus is enforced by powerful networks of inhibitory
GABAergic interneurons in combination with low intrinsic excitability of the principal …

Parallel visual pathways are initiated at the first retinal synapse by signaling between the rod
and cone photoreceptors and two general classes of bipolar cells. For normal function, ON …

Glutamate, an excitatory neurotransmitter, is essential for neuronal function, and it acts on
ionotropic or metabotropic glutamate receptors (mGluRs). A disturbance in glutamatergic …

Mutations in LRIT 3 lead to complete congenital stationary night blindness (cCSNB). The
exact role of LRIT 3 in ON‐bipolar cell signaling cascade remains to be elucidated …

Members of the R7 family of the regulators of G-protein signaling (R7 RGS) proteins form
multi-subunit complexes that play crucial roles in processing the light responses of retinal …