The Pictet-Spengler reaction (PS) is one of the most direct, efficient, and variable synthetic
method for the construction of privileged pharmacophores such as tetrahydro-isoquinolines …

The Horner-Wadsworth-Emmons reaction is one of the most reliable and widespread
synthetic tools for the stereocontrolled construction of ethylenic bonds. The versatility of the …

Nature uses sulfation of endogenous and exogenous molecules mainly to avoid potential
toxicity. The growing importance of natural sulfated molecules, as modulators of a number of …

Growing evidence suggests that plasmin is involved in a number of physiological processes
in addition to its key role in fibrin cleavage. Plasmin inhibition is critical in preventing …

Heparin, a sulfated polysaccharide belonging to the glycosaminoglycan family, has been
widely used as an anticoagulant drug for decades and remains the most commonly used …

Inhibition of factor XIa (FXIa) is a novel paradigm for developing anticoagulants without
major bleeding consequences. We present the discovery of sulfated pentagalloylglucoside …

We recently introduced sulfated pentagalloylglucopyranoside (SPGG) as an allosteric
inhibitor of factor XIa (FXIa)(Al-Horani et al., J. Med Chem. 2013, 56, 867–878). To better …

The blood coagulation factor XIII (FXIII) plays an essential role in the stabilization of fibrin
clots. This factor, belonging to the class of transglutaminases, catalyzes the final step of …

Highlights•Targeting serpins with drug-like molecules remains a challenge in drug
discovery.•Compounds targeting HSP47, antitrypsin, antithrombin, PAI-1 and neuroserpin …

Abstract Human factor XIIIa (FXIIIa) is a multifunctional transglutaminase with a significant
role in hemostasis. FXIIIa catalyzes the last step in the coagulation process. It stabilizes the …