Heteromeric α7β2 nicotinic acetylcholine receptors in the brain
The α7 nicotinic acetylcholine receptor (α7 nAChR) is highly expressed in the brain, where it
maintains various neuronal functions including (but not limited to) learning and memory. In …
maintains various neuronal functions including (but not limited to) learning and memory. In …
Alcohol‐binding sites in distinct brain proteins: the quest for atomic level resolution
Defining the sites of action of ethanol on brain proteins is a major prerequisite to
understanding the molecular pharmacology of this drug. The main barrier to reaching an …
understanding the molecular pharmacology of this drug. The main barrier to reaching an …
Structure of the pentameric ligand-gated ion channel GLIC bound with anesthetic ketamine
Pentameric ligand-gated ion channels (pLGICs) are targets of general anesthetics, but a
structural understanding of anesthetic action on pLGICs remains elusive. GLIC, a prokaryotic …
structural understanding of anesthetic action on pLGICs remains elusive. GLIC, a prokaryotic …
GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study
JA Ashby, IV McGonigle, KL Price, N Cohen… - Biophysical …, 2012 - cell.com
RDL receptors are GABA-activated inhibitory Cys-loop receptors found throughout the insect
CNS. They are a key target for insecticides. Here, we characterize the GABA binding site in …
CNS. They are a key target for insecticides. Here, we characterize the GABA binding site in …
[HTML][HTML] NMR structures of the human α7 nAChR transmembrane domain and associated anesthetic binding sites
V Bondarenko, DD Mowrey, TS Tillman… - … et Biophysica Acta (BBA …, 2014 - Elsevier
The α7 nicotinic acetylcholine receptor (nAChR), assembled as homomeric pentameric
ligand-gated ion channels, is one of the most abundant nAChR subtypes in the brain …
ligand-gated ion channels, is one of the most abundant nAChR subtypes in the brain …
Insights into distinct modulation of α7 and α7β2 nicotinic acetylcholine receptors by the volatile anesthetic isoflurane
Nicotinic acetylcholine receptors (nAChRs) are targets of general anesthetics, but functional
sensitivity to anesthetic inhibition varies dramatically among different subtypes of nAChRs …
sensitivity to anesthetic inhibition varies dramatically among different subtypes of nAChRs …
[HTML][HTML] NMR structures of the transmembrane domains of the α4β2 nAChR
The α4β2 nicotinic acetylcholine receptor (nAChR) is the predominant heteromeric subtype
of nAChRs in the brain, which has been implicated in numerous neurological conditions …
of nAChRs in the brain, which has been implicated in numerous neurological conditions …
Isoflurane alters the structure and dynamics of GLIC
Pentameric ligand-gated ion channels are targets of general anesthetics. Although the
search for discrete anesthetic binding sites has achieved some degree of success, little is …
search for discrete anesthetic binding sites has achieved some degree of success, little is …
[HTML][HTML] NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor
The nicotinic acetylcholine receptor (nAChR) is an important therapeutic target for a wide
range of pathophysiological conditions, for which rational drug designs often require …
range of pathophysiological conditions, for which rational drug designs often require …
Signal transduction pathways in the pentameric ligand-gated ion channels
The mechanisms of allosteric action within pentameric ligand-gated ion channels (pLGICs)
remain to be determined. Using crystallography, site-directed mutagenesis, and two …
remain to be determined. Using crystallography, site-directed mutagenesis, and two …