Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for
cellular homeostasis and adaption to stress. Accumulating evidence indicates that …

The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its
depletion has emerged as a fundamental feature of aging that may predispose to a wide …

The aging population is increasing in developed countries. Because the incidence of
cardiac disease increases dramatically with age, it is important to understand the molecular …

Genetic inhibition of autophagy induces degenerative changes in mammalian tissues that
resemble those associated with aging, and normal and pathological aging are often …

Dietary restriction (DR) is the most robust environmental manipulation known to increase
active and healthy lifespan in many species. Despite differences in the protocols and the …

Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …

Autophagy (self‐eating) is a conserved catabolic homeostatic process required for cellular
metabolic demands by removal of the damaged molecules and organelles and for …

Macroautophagy/autophagy is primarily accountable for the degradation of damaged
organelles and toxic macromolecules in the cells. Regarding the essential function of …

The ability to maintain a functional proteome, or proteostasis, declines during the ageing
process. Damaged and misfolded proteins accumulate with age, impairing cell function and …