While experimental and theoretical studies have established the prevalence of rhythmic
behaviour at all levels of biological organization, less common is the coexistence between …

Prostate cancer is the second most occurring cancer in men worldwide. To better
understand the mechanisms of tumorigenesis and possible treatment responses, we …

Interventions in gene regulatory networks (GRNs) aim to restore normal functions of cells
experiencing abnormal behavior, such as uncontrolled cell proliferation. The dynamic …

Logical models of cancer pathways are typically built by mining the literature for relevant
experimental observations. They are usually generic as they apply for large cohorts of …

Cells are constantly challenged by intrinsic and extrinsic signals. DNA damage denotes a
serious threat to cellular survival due to its extensive destroy to genomic integrity …

Birhythmicity arises in several physical, biological, and chemical systems. Although many
control schemes have been proposed for various forms of multistability, only a few exist for …

Birhythmicity occurs in many natural and artificial systems. In this paper, we propose a self-
feedback scheme to control birhythmicity. To establish the efficacy and generality of the …

Birhythmicity is evident in many nonlinear systems, which include physical and biological
systems. In some living systems, birhythmicity is necessary for response to the varying …

Gene regulatory networks control the response of living cells to changes in their
environment. A class of piecewise-linear (PWL) models, which capture the switch-like …

The cell cycle and the circadian clock represent two major cellular rhythms, which are
coupled because the circadian clock governs the synthesis of several proteins of the …